What genes are in the Global Genome Nucleotide Excision Repair (GG-NER) pathway?

The Global Genome Nucleotide Excision Repair (GG-NER) pathway involves 9 genes. Key genes include: CDK7, COPS5, ERCC3, PARP1, PCNA, POLK, RBX1, SUMO1, UBE2N.

Global Genome Nucleotide Excision Repair (GG-NER)

Q: What compounds affect the Global Genome Nucleotide Excision Repair (GG-NER) pathway?

76 compounds in the BiohacksAI corpus have documented interactions with genes in the Global Genome Nucleotide Excision Repair (GG-NER) pathway (Reactome ID: R-HSA-5696399). These compounds target 9 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-56963999 genes76 compounds

The Global Genome Nucleotide Excision Repair (GG-NER) pathway (Reactome ID: R-HSA-5696399) involves 9 genes and is affected by 76 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK7 COPS5 ERCC3 PARP1 PCNA POLK RBX1 SUMO1 UBE2N

Compounds Affecting Global Genome Nucleotide Excision Repair (GG-NER)

#	Compound	Targets Hit	Studies
1	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
2	Cefixime	—	300
3	Daunorubicin	—	298
4	DEAD-box RNA Helicases	—	169
5	Thioctic Acid	—	298
6	Resveratrol	—	298
7	Oxytetracycline	—	300
8	Thioctic Acid	—	300
9	Sphingosine	—	300
10	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
11	Quercetin	—	300
12	Ethidium	—	300
13	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
14	alpha-Linolenic Acid	—	300
15	Carmine Coloring matter from	—	300
16	Epinephrine	—	299
17	gamma-Linolenic Acid	—	300
18	Levodopa	—	297
19	Masoprocol	—	300
20	piceatannol	—	300
21	Arachidonic Acid	—	245
22	fisetin	—	78
23	candesartan cilexetil [Supplementary Concept]	—	300
24	Diiodotyrosine	—	300
25	Idarubicin	—	299
26	Methyldopa	—	297
27	Norepinephrine Precursor of epinephrine that is secreted by	—	298
28	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
29	Catechin	—	51
30	plumbagin [Supplementary Concept]	—	300
31	Rutin	—	300
32	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
33	Anthralin	—	299
34	Aurintricarboxylic Acid	—	184
35	butein	—	158
36	Cefotetan	—	299
37	Cimetidine	—	299
38	Demeclocycline	—	5
39	Dihydroxyphenylalanine	—	300
40	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
41	Catechin	—	300
42	Estramustine	—	300
43	o-Phthalaldehyde	—	300
44	rafoxanide	—	172
45	streptonigrin	—	299
46	Suramin	—	300
47	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
48	Bortezomib	—	300
49	Camptothecin	—	300
50	Clofarabine	—	298

About the Global Genome Nucleotide Excision Repair (GG-NER) Pathway

The Global Genome Nucleotide Excision Repair (GG-NER) pathway is catalogued in Reactome (ID: R-HSA-5696399) and involves 9 genes. In the BiohacksAI corpus, 76 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, COPS5, ERCC3, PARP1, PCNA.