Gap-filling DNA repair synthesis and ligation in TC-NER

Q: What compounds affect the Gap-filling DNA repair synthesis and ligation in TC-NER pathway?

53 compounds in the BiohacksAI corpus have documented interactions with genes in the Gap-filling DNA repair synthesis and ligation in TC-NER pathway (Reactome ID: R-HSA-6782210). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-67822106 genes53 compounds

The Gap-filling DNA repair synthesis and ligation in TC-NER pathway (Reactome ID: R-HSA-6782210) involves 6 genes and is affected by 53 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK7 ERCC3 PCNA POLK RBX1 USP7

Compounds Affecting Gap-filling DNA repair synthesis and ligation in TC-NER

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
3	alpha-Linolenic Acid	—	300
4	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
5	Ethidium	—	300
6	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
7	Carmine Coloring matter from	—	300
8	Epinephrine	—	299
9	gamma-Linolenic Acid	—	300
10	Levodopa	—	297
11	Masoprocol	—	300
12	piceatannol	—	300
13	Arachidonic Acid	—	245
14	fisetin	—	78
15	candesartan cilexetil [Supplementary Concept]	—	300
16	Cefixime	—	300
17	Daunorubicin	—	298
18	Diiodotyrosine	—	300
19	Idarubicin	—	299
20	Methyldopa	—	297
21	Norepinephrine Precursor of epinephrine that is secreted by	—	298
22	DEAD-box RNA Helicases	—	169
23	Thioctic Acid	—	298
24	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
25	Catechin	—	51
26	plumbagin [Supplementary Concept]	—	300
27	Resveratrol	—	298
28	Rutin	—	300
29	Ampicillin Semi-synthetic derivative of penicillin that functions as	—	294
30	Anthralin	—	299
31	Aurintricarboxylic Acid	—	184
32	butein	—	158
33	Cefotetan	—	299
34	Cimetidine	—	299
35	Demeclocycline	—	5
36	Dihydroxyphenylalanine	—	300
37	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
38	Catechin	—	300
39	Estramustine	—	300
40	o-Phthalaldehyde	—	300
41	Oxytetracycline	—	300
42	rafoxanide	—	172
43	streptonigrin	—	299
44	Suramin	—	300
45	Thioctic Acid	—	300
46	celastrol	—	300
47	hydroxyfasudil [Supplementary Concept]	—	11
48	pictilisib	—	25
49	Sorafenib	—	300
50	Oleanolic Acid	—	300

About the Gap-filling DNA repair synthesis and ligation in TC-NER Pathway

The Gap-filling DNA repair synthesis and ligation in TC-NER pathway is catalogued in Reactome (ID: R-HSA-6782210) and involves 6 genes. In the BiohacksAI corpus, 53 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK7, ERCC3, PCNA, POLK, RBX1.