What compounds affect the RET signaling pathway?

26 compounds in the BiohacksAI corpus have documented interactions with genes in the RET signaling pathway (Reactome ID: R-HSA-8853659). These compounds target 12 genes within this pathway.

What genes are in the RET signaling pathway?

The RET signaling pathway involves 12 genes. Key genes include: GRB2, MAPK7, PIK3CB, PIK3CD, PIK3R1, PIK3R2, PIK3R3, PRKACA, PRKACB, PRKACG.

RET signaling

REACTOME PATHWAY

Reactome: R-HSA-885365912 genes26 compounds

The RET signaling pathway (Reactome ID: R-HSA-8853659) involves 12 genes and is affected by 26 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

GRB2 MAPK7 PIK3CB PIK3CD PIK3R1 PIK3R2 PIK3R3 PRKACA PRKACB PRKACG RET SRC

Compounds Affecting RET signaling

#	Compound	Targets Hit	Studies
1	Sirolimus	—	300
2	pictilisib	—	25
3	ly294002	—	11
4	alpelisib	—	227
5	Crizotinib	—	298
6	Wortmannin	—	300
7	hydroxyfasudil [Supplementary Concept]	—	11
8	Dasatinib	—	299
9	Resveratrol	—	298
10	Sorafenib	—	300
11	Quercetin	—	300
12	torin 1	—	10
13	tyrphostin ag 1478	—	4
14	Adenosine Monophosphate Adenine nucleotide containing	—	300
15	Afatinib	—	297
16	alsterpaullone	—	12
17	kenpaullone	—	8
18	monorden	—	8
19	Niclosamide	—	299
20	Ku 0063794 [Supplementary Concept]	—	7
21	Axitinib	—	298
22	Nortriptyline	—	295
23	Amitriptyline Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent	—	299
24	sp600125	—	117
25	Sphingosine	—	300
26	Dactinomycin	—	297

About the RET signaling Pathway

The RET signaling pathway is catalogued in Reactome (ID: R-HSA-8853659) and involves 12 genes. In the BiohacksAI corpus, 26 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include GRB2, MAPK7, PIK3CB, PIK3CD, PIK3R1.