What genes are in the RUNX3 regulates BCL2L11 (BIM) transcription pathway?

The RUNX3 regulates BCL2L11 (BIM) transcription pathway involves 3 genes. Key genes include: BCL2L11, FOXO3, SMAD3.

RUNX3 regulates BCL2L11 (BIM) transcription

Q: What compounds affect the RUNX3 regulates BCL2L11 (BIM) transcription pathway?

65 compounds in the BiohacksAI corpus have documented interactions with genes in the RUNX3 regulates BCL2L11 (BIM) transcription pathway (Reactome ID: R-HSA-8952158). These compounds target 3 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-89521583 genes65 compounds

The RUNX3 regulates BCL2L11 (BIM) transcription pathway (Reactome ID: R-HSA-8952158) involves 3 genes and is affected by 65 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

BCL2L11 FOXO3 SMAD3

Compounds Affecting RUNX3 regulates BCL2L11 (BIM) transcription

#	Compound	Targets Hit	Studies
1	Anisomycin	—	247
2	Calcimycin	—	216
3	cycloheximide	—	300
4	alsterpaullone	—	12
5	Azacitidine	—	298
6	Azacitidine	—	300
7	Disulfiram	—	297
8	kenpaullone	—	8
9	Nisoldipine	—	297
10	Tubercidin	—	300
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Kaempferols	—	300
13	Quercetin	—	300
14	cardamonin	—	180
15	Colchicine	—	300
16	Dactinomycin	—	297
17	Danazol	—	298
18	Dasatinib	—	299
19	Dinitrochlorobenzene	—	300
20	Ethidium	—	300
21	Flutamide	—	298
22	Loratadine	—	296
23	Oxyphenbutazone	—	300
24	Podophyllotoxin	—	14
25	vinblastine sulfate	—	81
26	Vincristine	—	299
27	chrysin	—	300
28	egcg	—	300
29	Fluoxetine	—	1,000
30	Methylene Blue	—	200
31	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
32	Astemizole Antihistamine drug now withdrawn from	—	280
33	Bortezomib	—	300
34	Celecoxib	—	295
35	Ciclopirox	—	88
36	Cladribine	—	297
37	Daunorubicin	—	298
38	Digitoxin	—	300
39	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	—	300
40	Dithiazanine 3-Ethyl-2-(5-(3-ethyl-2-benzothiazolinylidene)-1,3- pentadienyl)benzothiazolium.	—	135
41	Domperidone	—	299
42	Emetine	—	298
43	Equilin	—	216
44	Ethinyl Estradiol	—	300
45	Ezetimibe	—	296
46	Fluspirilene	—	74
47	Hexachlorophene	—	300
48	Idazoxan	—	300
49	Lynestrenol	—	299
50	Nocodazole Nocodazole is	—	215

About the RUNX3 regulates BCL2L11 (BIM) transcription Pathway

The RUNX3 regulates BCL2L11 (BIM) transcription pathway is catalogued in Reactome (ID: R-HSA-8952158) and involves 3 genes. In the BiohacksAI corpus, 65 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include BCL2L11, FOXO3, SMAD3.