What compounds affect the Biosynthesis of EPA-derived SPMs pathway?

109 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of EPA-derived SPMs pathway (Reactome ID: R-HSA-9018679). These compounds target 6 genes within this pathway.

What genes are in the Biosynthesis of EPA-derived SPMs pathway?

The Biosynthesis of EPA-derived SPMs pathway involves 6 genes. Key genes include: ALOX15, ALOX5, GPX4, HPGD, LTA4H, PTGS2.

Biosynthesis of EPA-derived SPMs

REACTOME PATHWAY

Reactome: R-HSA-90186796 genes109 compounds

The Biosynthesis of EPA-derived SPMs pathway (Reactome ID: R-HSA-9018679) involves 6 genes and is affected by 109 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX15 ALOX5 GPX4 HPGD LTA4H PTGS2

Compounds Affecting Biosynthesis of EPA-derived SPMs

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Masoprocol	—	300
3	Celecoxib	—	295
4	Indomethacin	—	297
5	Arachidonic Acid	—	245
6	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
7	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
8	Hexachlorophene	—	300
9	Resveratrol	—	298
10	pterostilbene	—	299
11	cbd	—	298
12	butein	—	158
13	cannabidiol	—	296
14	Methyldopa	—	297
15	Niflumic Acid	—	300
16	Procarbazine	—	299
17	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
18	Dipyrone	—	298
19	Ethidium	—	300
20	Ethoxyquin Antioxidant; also	—	180
21	juglone hydroxylase [Supplementary Concept] catalyzes	—	279
22	Linoleic Acid	—	300
23	Kaempferols	—	300
24	Leukotriene A4 (2S-(2 alpha,3 beta(1E,3E,5Z,8Z)))-3-(1,3,5,8-Tetradecatetraenyl)oxiranebutanoic acid.	—	300
25	ns398	—	116
26	Meloxicam	—	299
27	Naproxen	—	1,000
28	Etodolac	—	296
29	sulindac sulfide	—	79
30	aphs	—	7
31	Oxaprozin	—	181
32	sc560	—	13
33	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
34	Ursolic Acid	—	300
35	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
36	Acetylcysteine	—	298
37	Calcitriol	—	300
38	Cephradine	—	298
39	Daunorubicin	—	298
40	Epinephrine	—	299
41	Ergotamine	—	299
42	Hesperidin	—	300
43	Indapamide	—	299
44	isoetharine	—	112
45	Lymecycline	—	143
46	monorden	—	8
47	Norepinephrine Precursor of epinephrine that is secreted by	—	298
48	Noscapine	—	300
49	Oxymetazoline	—	298
50	Oxymetholone	—	298

About the Biosynthesis of EPA-derived SPMs Pathway

The Biosynthesis of EPA-derived SPMs pathway is catalogued in Reactome (ID: R-HSA-9018679) and involves 6 genes. In the BiohacksAI corpus, 109 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX15, ALOX5, GPX4, HPGD, LTA4H.