What compounds affect the Biosynthesis of DPA-derived SPMs pathway?

94 compounds in the BiohacksAI corpus have documented interactions with genes in the Biosynthesis of DPA-derived SPMs pathway (Reactome ID: R-HSA-9018683). These compounds target 4 genes within this pathway.

What genes are in the Biosynthesis of DPA-derived SPMs pathway?

The Biosynthesis of DPA-derived SPMs pathway involves 4 genes. Key genes include: ALOX12, ALOX15, ALOX5, PTGS2.

Biosynthesis of DPA-derived SPMs

REACTOME PATHWAY

Reactome: R-HSA-90186834 genes94 compounds

The Biosynthesis of DPA-derived SPMs pathway (Reactome ID: R-HSA-9018683) involves 4 genes and is affected by 94 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ALOX12 ALOX15 ALOX5 PTGS2

Compounds Affecting Biosynthesis of DPA-derived SPMs

#	Compound	Targets Hit	Studies
1	Quercetin	—	300
2	Celecoxib	—	295
3	butein	—	158
4	Procarbazine	—	299
5	Masoprocol	—	300
6	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
7	Indomethacin	—	297
8	Resveratrol	—	298
9	Arachidonic Acid	—	245
10	pterostilbene	—	299
11	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
12	Epinephrine	—	299
13	isoetharine	—	112
14	fisetin	—	78
15	Hexachlorophene	—	300
16	piceatannol	—	300
17	Dipyrone	—	298
18	ethopropazine hydrochloride	—	2
19	ns398	—	116
20	Meloxicam	—	299
21	Naproxen	—	1,000
22	Etodolac	—	296
23	sulindac sulfide	—	79
24	aphs	—	7
25	Oxaprozin	—	181
26	sc560	—	13
27	cbd	—	298
28	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	1,000
29	Ursolic Acid	—	300
30	Acetaminophen Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as	—	293
31	Acetylcysteine	—	298
32	Calcitriol	—	300
33	cannabidiol	—	296
34	Cephradine	—	298
35	Daunorubicin	—	298
36	Ergotamine	—	299
37	Hesperidin	—	300
38	Indapamide	—	299
39	Lymecycline	—	143
40	Methyldopa	—	297
41	monorden	—	8
42	Niflumic Acid	—	300
43	Norepinephrine Precursor of epinephrine that is secreted by	—	298
44	Noscapine	—	300
45	Oxymetazoline	—	298
46	Oxymetholone	—	298
47	Phenylbutazone	—	300
48	Rifaximin	—	298
49	Rolitetracycline	—	166
50	Sorafenib	—	300

About the Biosynthesis of DPA-derived SPMs Pathway

The Biosynthesis of DPA-derived SPMs pathway is catalogued in Reactome (ID: R-HSA-9018683) and involves 4 genes. In the BiohacksAI corpus, 94 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ALOX12, ALOX15, ALOX5, PTGS2.