What compounds affect the MECP2 regulates transcription factors pathway?

112 compounds in the BiohacksAI corpus have documented interactions with genes in the MECP2 regulates transcription factors pathway (Reactome ID: R-HSA-9022707). These compounds target 2 genes within this pathway.

What genes are in the MECP2 regulates transcription factors pathway?

The MECP2 regulates transcription factors pathway involves 2 genes. Key genes include: CREB1, PPARG.

MECP2 regulates transcription factors

REACTOME PATHWAY

Reactome: R-HSA-90227072 genes112 compounds

The MECP2 regulates transcription factors pathway (Reactome ID: R-HSA-9022707) involves 2 genes and is affected by 112 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 PPARG

Compounds Affecting MECP2 regulates transcription factors

#	Compound	Targets Hit	Studies
1	Genistein	—	300
2	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
3	chrysin	—	300
4	Disulfiram	—	297
5	Ethidium	—	300
6	o-Phthalaldehyde	—	300
7	trequinsin hydrochloride	—	1
8	Quercetin	—	300
9	cycloheximide	—	300
10	Dactinomycin	—	297
11	Dasatinib	—	299
12	Daunorubicin	—	298
13	Nocodazole Nocodazole is	—	215
14	Sulbactam	—	299
15	Pioglitazone	—	297
16	Troglitazone	—	299
17	Methylene Blue	—	200
18	Thyroxine	—	994
19	Thyroxine	—	300
20	Indomethacin	—	297
21	Warfarin	—	1,000
22	Glyburide	—	298
23	Rotenone	—	300
24	urolithin b	—	49
25	alpha-Linolenic Acid	—	300
26	Bezafibrate	—	300
27	Linoleic Acid	—	300
28	Mycophenolic Acid Compound derived from Penicillium stoloniferum and related species. It blocks de novo biosynthesis of purine nucleotides by inhibition of	—	300
29	sulindac sulfide	—	79
30	Triiodothyronine	—	300
31	Kaempferols	—	300
32	Resveratrol	—	298
33	candesartan cilexetil [Supplementary Concept]	—	300
34	Ethoxyquin Antioxidant; also	—	180
35	Glutaral	—	42
36	Loratadine	—	296
37	Losartan	—	1,000
38	Mepentol [Supplementary Concept]	—	184
39	Dinitrochlorobenzene	—	300
40	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
41	Fenofibrate	—	297
42	Feprazone	—	63
43	lonidamine	—	300
44	Maprotiline	—	299
45	Niflumic Acid	—	300
46	Oxaprozin	—	181
47	Prostaglandin D2	—	300
48	Spironolactone	—	298
49	Thioridazine	—	35
50	trichostatic acid [Supplementary Concept] related to trichostatin	—	300

About the MECP2 regulates transcription factors Pathway

The MECP2 regulates transcription factors pathway is catalogued in Reactome (ID: R-HSA-9022707) and involves 2 genes. In the BiohacksAI corpus, 112 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, PPARG.