What compounds affect the NGF-stimulated transcription pathway?

61 compounds in the BiohacksAI corpus have documented interactions with genes in the NGF-stimulated transcription pathway (Reactome ID: R-HSA-9031628). These compounds target 8 genes within this pathway.

What genes are in the NGF-stimulated transcription pathway?

The NGF-stimulated transcription pathway involves 8 genes. Key genes include: CDK5, CDK5R1, CREB1, EP300, F3, FOS, ID4, SGK1.

NGF-stimulated transcription

REACTOME PATHWAY

Reactome: R-HSA-90316288 genes61 compounds

The NGF-stimulated transcription pathway (Reactome ID: R-HSA-9031628) involves 8 genes and is affected by 61 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK5 CDK5R1 CREB1 EP300 F3 FOS ID4 SGK1

Compounds Affecting NGF-stimulated transcription

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	chrysin	—	300
3	egcg	—	300
4	Masoprocol	—	300
5	kenpaullone	—	8
6	alsterpaullone	—	12
7	indirubin	—	300
8	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
9	fisetin	—	78
10	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
11	sp600125	—	117
12	cycloheximide	—	300
13	Disulfiram	—	297
14	Azacitidine	—	298
15	Azacitidine	—	300
16	Levalbuterol	—	1,000
17	Adenosine Monophosphate Adenine nucleotide containing	—	300
18	Levalbuterol	—	297
19	Bortezomib	—	300
20	Clofarabine	—	298
21	Dactinomycin	—	297
22	Danazol	—	298
23	Emetine	—	298
24	Ethidium	—	300
25	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
26	Sulbactam	—	299
27	trequinsin hydrochloride	—	1
28	Genistein	—	300
29	Quercetin	—	300
30	Testosterone	—	299
31	Ciclopirox	—	88
32	Cladribine	—	297
33	Clenbuterol	—	300
34	Corticosterone	—	300
35	Dasatinib	—	299
36	Daunorubicin	—	298
37	Dinoprostone	—	296
38	Epinephrine	—	299
39	Ethinyl Estradiol	—	300
40	Imatinib Mesylate	—	300
41	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
42	Nisoldipine	—	297
43	Nocodazole Nocodazole is	—	215
44	Norepinephrine Precursor of epinephrine that is secreted by	—	298
45	o-Phthalaldehyde	—	300
46	Oxyphenbutazone	—	300
47	pivampicillin	—	275
48	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
49	Salmeterol Xinafoate	—	227
50	Tilorone	—	300

About the NGF-stimulated transcription Pathway

The NGF-stimulated transcription pathway is catalogued in Reactome (ID: R-HSA-9031628) and involves 8 genes. In the BiohacksAI corpus, 61 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK5, CDK5R1, CREB1, EP300, F3.