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BiohacksAI

Evidence-Based Biohacking

Patent Pending

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

REACTOME PATHWAY
Reactome: R-HSA-96095232 genes37 compounds

The Insertion of tail-anchored proteins into the endoplasmic reticulum membrane pathway (Reactome ID: R-HSA-9609523) involves 2 genes and is affected by 37 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

APPPRNP

Compounds Affecting Insertion of tail-anchored proteins into the endoplasmic reticulum membrane

#CompoundTargets HitStudies
1Resveratrol—298
2Quercetin—300
3egcg—300
4Hesperidin—300
5myricetin-3-O-galactopyranoside [Supplementary Concept]—300
6Kaempferols—300
7Methylene Blue—200
8Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
9(N-methyl-C-11)-2-(4-methylamino-phenyl)-6-hydroxybenzothiazole [Supplementary Concept] neutral analog of amyloid-binding thioflavin-T (BTA) that crosses—300
10Apigenin 5,7,4'-trihydroxy-flavone,—300
11caffeic acid—300
12Vitamin—295
132-Methoxyestradiol—300
14arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from—300
15Cladribine—297
16Digitoxin—300
17Digoxin—299
18Disulfiram—297
19Edetic Acid—24
20Catechin—300
21Vanillic Acid—300
22Ouabain—300
23Podophyllotoxin—14
24Quinic Acid—218
25Retinaldehyde—300
26streptonigrin—299
27Trifluridine—295
28Anisomycin—247
29cycloheximide—300
30torin 1—10
31Tubercidin—300
32urolithin b—49
33Azacitidine—298
34Azacitidine—300
35Dasatinib—299
36Hexachlorophene—300
37Promethazine—296

About the Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Pathway

The Insertion of tail-anchored proteins into the endoplasmic reticulum membrane pathway is catalogued in Reactome (ID: R-HSA-9609523) and involves 2 genes. In the BiohacksAI corpus, 37 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include APP, PRNP.