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Promethazine

A phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. It is used as an antiallergic, in pruritus, for motion sickness and sedation, and also in animals.

296+ PubMed studies analyzed · 23 RCTs · Evidence Score: 43.1

Research Domains

Promethazine has been studied across 19 research domains including 😴 Sleep, 💊 Pain, ❤️ Cardiovascular, 🫁 Respiratory, 🫁 Liver & Detox. The primary research focus is 😴 Sleep with 13% of studies addressing this area.

Similar Compounds by Shared Targets

The following compounds share molecular targets with Promethazine, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.

Cinnarizine
33 shared targets
Mianserin
39 shared targets
Amoxapine
44 shared targets
Cyproheptadine
40 shared targets
Nortriptyline
39 shared targets
Maprotiline
37 shared targets
Quetiapine
31 shared targets
Amitriptyline
40 shared targets
Flunarizine
34 shared targets
Metergoline
40 shared targets
Loading evidence profile...

This evidence profile for Promethazine is generated deterministically from 296 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.