What compounds affect the GPER1 signaling pathway?

48 compounds in the BiohacksAI corpus have documented interactions with genes in the GPER1 signaling pathway (Reactome ID: R-HSA-9634597). These compounds target 8 genes within this pathway.

What genes are in the GPER1 signaling pathway?

The GPER1 signaling pathway involves 8 genes. Key genes include: ADCY9, GNAI1, GNAS, GPER1, PRKACA, PRKACB, PRKACG, SRC.

GPER1 signaling

REACTOME PATHWAY

Reactome: R-HSA-96345978 genes48 compounds

The GPER1 signaling pathway (Reactome ID: R-HSA-9634597) involves 8 genes and is affected by 48 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 GNAI1 GNAS GPER1 PRKACA PRKACB PRKACG SRC

Compounds Affecting GPER1 signaling

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Aurintricarboxylic Acid	—	184
3	tyrphostin ag 1478	—	4
4	Niclosamide	—	299
5	Daunorubicin	—	298
6	Ethidium	—	300
7	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
8	Rosmarinic Acid	—	300
9	Allantoin	—	300
10	Diiodotyrosine	—	300
11	Dimethylphenylpiperazinium Iodide	—	33
12	Dipyrone	—	298
13	Idarubicin	—	299
14	iodoform	—	272
15	Nicergoline	—	300
16	Pseudoephedrine	—	298
17	Riboflavin Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables.	—	297
18	tiopronin	—	299
19	Carmustine	—	297
20	Edaravone	—	298
21	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
22	Iodoacetamide	—	300
23	Cisplatin	—	300
24	Cilostazol	—	297
25	Disulfiram	—	297
26	Physostigmine	—	300
27	Ethylmaleimide	—	300
28	Physostigmine	—	299
29	tyrphostin 1	—	1
30	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
31	arctigenin-4-O-(3''-O-acetyl-beta-D-glucoside) [Supplementary Concept] isolated from	—	300
32	Diamide	—	300
33	Dasatinib	—	299
34	Resveratrol	—	298
35	Sorafenib	—	300
36	Quercetin	—	300
37	Adenosine Monophosphate Adenine nucleotide containing	—	300
38	Afatinib	—	297
39	alsterpaullone	—	12
40	Crizotinib	—	298
41	kenpaullone	—	8
42	monorden	—	8
43	Tetraethylammonium	—	119
44	Triacetin	—	300
45	urolithin b	—	49
46	alpelisib	—	227
47	Sphingosine	—	300
48	Fulvestrant	—	295

About the GPER1 signaling Pathway

The GPER1 signaling pathway is catalogued in Reactome (ID: R-HSA-9634597) and involves 8 genes. In the BiohacksAI corpus, 48 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, GNAI1, GNAS, GPER1, PRKACA.