ADORA2B mediated anti-inflammatory cytokines production

Q: What compounds affect the ADORA2B mediated anti-inflammatory cytokines production pathway?

80 compounds in the BiohacksAI corpus have documented interactions with genes in the ADORA2B mediated anti-inflammatory cytokines production pathway (Reactome ID: R-HSA-9660821). These compounds target 10 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-966082110 genes80 compounds

The ADORA2B mediated anti-inflammatory cytokines production pathway (Reactome ID: R-HSA-9660821) involves 10 genes and is affected by 80 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADCY9 ADORA2B CREB1 GNAI1 GNAS IL6 PRKACA PRKACB PRKACG PRKX

Compounds Affecting ADORA2B mediated anti-inflammatory cytokines production

#	Compound	Targets Hit	Studies
1	hydroxyfasudil [Supplementary Concept]	—	11
2	Disulfiram	—	297
3	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
4	Ethidium	—	300
5	Daunorubicin	—	298
6	Aurintricarboxylic Acid	—	184
7	cycloheximide	—	300
8	Azacitidine	—	298
9	Azacitidine	—	300
10	Levalbuterol	—	1,000
11	Adenosine Monophosphate Adenine nucleotide containing	—	300
12	Levalbuterol	—	297
13	Bortezomib	—	300
14	Clofarabine	—	298
15	Dactinomycin	—	297
16	Danazol	—	298
17	Emetine	—	298
18	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
19	Sulbactam	—	299
20	trequinsin hydrochloride	—	1
21	chrysin	—	300
22	Genistein	—	300
23	Quercetin	—	300
24	Testosterone	—	299
25	Ciclopirox	—	88
26	Cladribine	—	297
27	Clenbuterol	—	300
28	Corticosterone	—	300
29	Dasatinib	—	299
30	Dinoprostone	—	296
31	Epinephrine	—	299
32	Ethinyl Estradiol	—	300
33	Imatinib Mesylate	—	300
34	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
35	Nisoldipine	—	297
36	Nocodazole Nocodazole is	—	215
37	Masoprocol	—	300
38	Norepinephrine Precursor of epinephrine that is secreted by	—	298
39	o-Phthalaldehyde	—	300
40	Oxyphenbutazone	—	300
41	pivampicillin	—	275
42	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
43	Salmeterol Xinafoate	—	227
44	Tilorone	—	300
45	Urea	—	297
46	Rosmarinic Acid	—	300
47	Allantoin	—	300
48	Diiodotyrosine	—	300
49	Dimethylphenylpiperazinium Iodide	—	33
50	Dipyrone	—	298

About the ADORA2B mediated anti-inflammatory cytokines production Pathway

The ADORA2B mediated anti-inflammatory cytokines production pathway is catalogued in Reactome (ID: R-HSA-9660821) and involves 10 genes. In the BiohacksAI corpus, 80 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADCY9, ADORA2B, CREB1, GNAI1, GNAS.