Sensory processing of sound by inner hair cells of the cochlea

Q: What compounds affect the Sensory processing of sound by inner hair cells of the cochlea pathway?

47 compounds in the BiohacksAI corpus have documented interactions with genes in the Sensory processing of sound by inner hair cells of the cochlea pathway (Reactome ID: R-HSA-9662360). These compounds target 7 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-96623607 genes47 compounds

The Sensory processing of sound by inner hair cells of the cochlea pathway (Reactome ID: R-HSA-9662360) involves 7 genes and is affected by 47 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CACNA1D CACNA2D2 CASK KCNMA1 KCNMB1 MYO3A MYO3B

Compounds Affecting Sensory processing of sound by inner hair cells of the cochlea

#	Compound	Targets Hit	Studies
1	Nisoldipine	—	297
2	Budesonide	—	1,000
3	pterostilbene	—	299
4	Carvedilol	—	296
5	Fluocinolone Acetonide	—	295
6	Latanoprost	—	299
7	Promethazine	—	121
8	Thioridazine	—	35
9	Amoxapine	—	259
10	nafadotride	—	14
11	3',4'-didemethylnobiletin [Supplementary Concept]	—	300
12	Nortriptyline	—	28
13	Perphenazine	—	297
14	Ritonavir	—	298
15	Resveratrol	—	298
16	Ethylestrenol	—	70
17	Ezetimibe	—	296
18	Glyburide	—	298
19	Irbesartan	—	298
20	Oxaprozin	—	181
21	Thyroxine	—	994
22	Simvastatin	—	1,000
23	Calcitriol	—	300
24	Chlorpheniramine	—	157
25	Desoximetasone	—	86
26	Disulfiram	—	297
27	Etodolac	—	296
28	Levonorgestrel	—	292
29	Norgestrel	—	300
30	Oxcarbazepine	—	296
31	Thyroxine	—	300
32	Ursodeoxycholic Acid	—	298
33	Flutamide	—	298
34	Imatinib Mesylate	—	300
35	Lovastatin	—	300
36	L 741519 [Supplementary Concept]	—	25
37	Torsemide	—	245
38	Vecuronium Bromide Monoquaternary homolog of PANCURONIUM.	—	298
39	Nitrendipine	—	299
40	Amlodipine	—	1,000
41	Duloxetine Hydrochloride	—	993
42	Astemizole Antihistamine drug now withdrawn from	—	280
43	Quinidine	—	298
44	Pregabalin	—	996
45	Axitinib	—	298
46	Crizotinib	—	298
47	Sorafenib	—	300

About the Sensory processing of sound by inner hair cells of the cochlea Pathway

The Sensory processing of sound by inner hair cells of the cochlea pathway is catalogued in Reactome (ID: R-HSA-9662360) and involves 7 genes. In the BiohacksAI corpus, 47 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CACNA1D, CACNA2D2, CASK, KCNMA1, KCNMB1.