What genes are in the Mitochondrial unfolded protein response (UPRmt) pathway?

The Mitochondrial unfolded protein response (UPRmt) pathway involves 8 genes. Key genes include: ESR1, FOXO3, HSPA1A, HSPA1B, HSPD1, HSPE1, LONP1, SIRT3.

Mitochondrial unfolded protein response (UPRmt)

Q: What compounds affect the Mitochondrial unfolded protein response (UPRmt) pathway?

264 compounds in the BiohacksAI corpus have documented interactions with genes in the Mitochondrial unfolded protein response (UPRmt) pathway (Reactome ID: R-HSA-9841251). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-98412518 genes264 compounds

The Mitochondrial unfolded protein response (UPRmt) pathway (Reactome ID: R-HSA-9841251) involves 8 genes and is affected by 264 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ESR1 FOXO3 HSPA1A HSPA1B HSPD1 HSPE1 LONP1 SIRT3

Compounds Affecting Mitochondrial unfolded protein response (UPRmt)

#	Compound	Targets Hit	Studies
1	Hexachlorophene	—	300
2	Adapalene	—	296
3	rafoxanide	—	172
4	Aurintricarboxylic Acid	—	184
5	Resveratrol	—	298
6	Bortezomib	—	300
7	Arachidonic Acid	—	245
8	egcg	—	300
9	plumbagin [Supplementary Concept]	—	300
10	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
11	Evans Blue	—	300
12	Lithocholic Acid	—	300
13	Adenosine Diphosphate Adenosine 5'-(trihydrogen diphosphate).	—	300
14	Ergosterol	—	300
15	Adenosine Triphosphate	—	300
16	Levonorgestrel	—	292
17	Norgestrel	—	300
18	Ethinyl Estradiol	—	300
19	Genistein	—	300
20	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	—	300
21	Methyltestosterone	—	300
22	Dehydroepiandrosterone	—	300
23	Dehydroepiandrosterone	—	300
24	Fulvestrant	—	295
25	Kaempferols	—	300
26	Dactinomycin	—	297
27	Danazol	—	298
28	Estrone	—	300
29	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	—	119
30	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	—	300
31	Rotenone	—	300
32	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
33	Dihydrotestosterone	—	300
34	Ethidium	—	300
35	Ethynodiol Diacetate	—	300
36	Flutamide	—	298
37	Reserpine	—	297
38	Colchicine	—	300
39	Estriol	—	300
40	Mestranol	—	300
41	Norethindrone	—	300
42	Oxymetholone	—	298
43	Testosterone Propionate	—	300
44	cycloheximide	—	300
45	Gestrinone	—	221
46	Lynestrenol	—	299
47	Phenoxybenzamine	—	21
48	Pueraria	—	300
49	Digoxin	—	299
50	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300

About the Mitochondrial unfolded protein response (UPRmt) Pathway

The Mitochondrial unfolded protein response (UPRmt) pathway is catalogued in Reactome (ID: R-HSA-9841251) and involves 8 genes. In the BiohacksAI corpus, 264 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ESR1, FOXO3, HSPA1A, HSPA1B, HSPD1.