What compounds target ESR1?

BiohacksAI has identified 253 compounds that interact with ESR1 (estrogen receptor 1). Top compounds include: Levonorgestrel, Norgestrel, Resveratrol, Ethinyl Estradiol, Genistein. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is ESR1 (estrogen receptor 1)?

ESR1 is estrogen receptor 1. It is a molecular target for 253 compounds documented in PubMed bioassay data. UniProt ID: P03372. NCBI Gene ID: 2099.

ESR1

MOLECULAR TARGET

estrogen receptor 1

UniProt: P03372 NCBI Gene: 2099253 compounds

ESR1 (estrogen receptor 1) is targeted by 253 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting ESR1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Levonorgestrel	3.09	21
2	Norgestrel	3.09	21
3	Resveratrol	3.04	20
4	Ethinyl Estradiol	3.00	19
5	Genistein	2.94	18
6	Zearalenone (S-(E))-3,4,5,6,8,10-Hexahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradec in-1,7(8H)-dione.	2.94	18
7	Methyltestosterone	2.83	16
8	Dehydroepiandrosterone	2.77	15
9	Dehydroepiandrosterone	2.77	15
10	Fulvestrant	2.77	15
11	Kaempferols	2.71	14
12	Dactinomycin	2.71	14
13	Danazol	2.71	14
14	Estrone	2.71	14
15	Ethisterone 17 alpha-Hydroxypregn-4-en-20-yn-3-one.	2.64	13
16	Nandrolone C18 steroid with androgenic and anabolic properties. It is generally prepared from alkyl ethers of ESTRADIOL to resemble TESTOSTERONE but less	2.64	13
17	Rotenone	2.64	13
18	Apigenin 5,7,4'-trihydroxy-flavone,	2.56	12
19	Dihydrotestosterone	2.56	12
20	Ethidium	2.56	12
21	Ethynodiol Diacetate	2.56	12
22	Flutamide	2.56	12
23	Reserpine	2.56	12
24	Colchicine	2.48	11
25	Estriol	2.48	11
26	Mestranol	2.48	11
27	Norethindrone	2.48	11
28	Oxymetholone	2.48	11
29	Testosterone Propionate	2.48	11
30	cycloheximide	2.40	10
31	Gestrinone	2.40	10
32	Hexachlorophene	2.40	10
33	Lynestrenol	2.40	10
34	Phenoxybenzamine	2.40	10
35	Pueraria	2.30	9
36	Digoxin	2.30	9
37	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	2.30	9
38	Progesterone	2.20	8
39	Vitamin	2.20	8
40	Bortezomib	2.20	8
41	mg624	2.20	8
42	Trabectedin	2.20	8
43	propyl gallate	2.08	7
44	Niclosamide	2.08	7
45	Triiodothyronine	2.08	7
46	vinblastine sulfate	2.08	7
47	Celecoxib	1.95	6
48	Equilin	1.95	6
49	Loratadine	1.95	6
50	Melphalan	1.95	6

Showing top 50 of 253 compounds. Use the BiohacksAI search to explore all ESR1 modulators.

About ESR1 as a Drug Target

ESR1 (estrogen receptor 1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 253 compounds with documented ESR1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

ESR1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.