What compounds affect the Signaling by LTK in cancer pathway?

30 compounds in the BiohacksAI corpus have documented interactions with genes in the Signaling by LTK in cancer pathway (Reactome ID: R-HSA-9842640). These compounds target 5 genes within this pathway.

What genes are in the Signaling by LTK in cancer pathway?

The Signaling by LTK in cancer pathway involves 5 genes. Key genes include: MAPK1, MAPK3, PIK3CB, PIK3R1, PIK3R2.

Signaling by LTK in cancer

REACTOME PATHWAY

Reactome: R-HSA-98426405 genes30 compounds

The Signaling by LTK in cancer pathway (Reactome ID: R-HSA-9842640) involves 5 genes and is affected by 30 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

MAPK1 MAPK3 PIK3CB PIK3R1 PIK3R2

Compounds Affecting Signaling by LTK in cancer

#	Compound	Targets Hit	Studies
1	pictilisib	—	25
2	ly294002	—	11
3	Sirolimus	—	300
4	plumbagin [Supplementary Concept]	—	300
5	pd98059	—	7
6	alsterpaullone	—	12
7	kenpaullone	—	8
8	isorhamnetin-3-O-beta-D-glucopyranosyl-(1-3)-alpha-L-rhamnopyranosyl-(1-6)-beta-D-galactopyranoside [Supplementary Concept] from	—	300
9	Sorafenib	—	300
10	trametinib	—	296
11	withaferin	—	300
12	Wortmannin	—	300
13	alpelisib	—	227
14	tyrphostin ag 1478	—	4
15	Clotrimazole	—	296
16	sp600125	—	117
17	fisetin	—	78
18	Progesterone	—	299
19	2-Chloroadenosine 2-Chloroadenosine.	—	300
20	Benzalkonium Compounds	—	299
21	Calcimycin	—	216
22	daph	—	2
23	Diphenhydramine	—	14
24	ha1004	—	4
25	Lithocholic Acid	—	300
26	Loratadine	—	296
27	trequinsin hydrochloride	—	1
28	torin 1	—	10
29	Quercetin	—	300
30	Resveratrol	—	298

About the Signaling by LTK in cancer Pathway

The Signaling by LTK in cancer pathway is catalogued in Reactome (ID: R-HSA-9842640) and involves 5 genes. In the BiohacksAI corpus, 30 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include MAPK1, MAPK3, PIK3CB, PIK3R1, PIK3R2.