B

BiohacksAI

Evidence-Based Biohacking

Patent Pending

AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)

REACTOME PATHWAY
Reactome: R-HSA-993126940 genes32 compounds

The AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) pathway (Reactome ID: R-HSA-9931269) involves 40 genes and is affected by 32 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

ADRM1PRKAA1PRKAA2PRKAB1PRKAB2PRKAG1PRKAG2PRKAG3PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMB1PSMB2PSMB3PSMB4PSMB5PSMB6PSMB7PSMC1PSMC2PSMC3PSMC4PSMC5PSMC6PSMD1PSMD11+10 more

Compounds Affecting AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)

#CompoundTargets HitStudies
1Bortezomib—300
2Reserpine—297
3Adenosine Monophosphate Adenine nucleotide containing—300
4Proguanil—299
5Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone—76
6Niclosamide—299
7Berberine—300
8Ursolic Acid—300
9Antimycin—300
10Oleanolic Acid—300
11Rotenone—300
12Metformin—1,000
13Quercetin—300
14egcg—300
15Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as—300
16Kaempferols—300
17Rutin—300
18Disulfiram—297
194-Hydroxybenzoate-3-Monooxygenase—300
20Apigenin 5,7,4'-trihydroxy-flavone,—300
21chrysin—300
22Luteolin 5,7,3',4'-tetrahydroxy-flavone,—150
23Genistein—300
24myricetin-3-O-galactopyranoside [Supplementary Concept]—300
25Crizotinib—298
26Hexachlorophene—300
27Oxytetracycline—300
28Clotrimazole—296
29Demeclocycline—5
30Edaravone—298
31Pioglitazone—297
32Harmaline—300

About the AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Pathway

The AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) pathway is catalogued in Reactome (ID: R-HSA-9931269) and involves 40 genes. In the BiohacksAI corpus, 32 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include ADRM1, PRKAA1, PRKAA2, PRKAB1, PRKAB2.