Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

Q: What compounds affect the Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes pathway?

60 compounds in the BiohacksAI corpus have documented interactions with genes in the Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes pathway (Reactome ID: R-HSA-9931510). These compounds target 6 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-99315106 genes60 compounds

The Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes pathway (Reactome ID: R-HSA-9931510) involves 6 genes and is affected by 60 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CREB1 CREBBP KMT2A NR1D1 RORA SIK1

Compounds Affecting Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes

#	Compound	Targets Hit	Studies
1	Cladribine	—	297
2	Dasatinib	—	299
3	Nocodazole Nocodazole is	—	215
4	cycloheximide	—	300
5	Disulfiram	—	297
6	Azacitidine	—	298
7	Azacitidine	—	300
8	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
9	Levalbuterol	—	1,000
10	Adenosine Monophosphate Adenine nucleotide containing	—	300
11	Levalbuterol	—	297
12	Bortezomib	—	300
13	Clofarabine	—	298
14	Dactinomycin	—	297
15	Danazol	—	298
16	Emetine	—	298
17	Ethidium	—	300
18	Isopentenyladenosine N(6)-[delta(3)-isopentenyl]adenosine. Isopentenyl derivative of adenosine which is	—	270
19	Sulbactam	—	299
20	trequinsin hydrochloride	—	1
21	chrysin	—	300
22	Genistein	—	300
23	Quercetin	—	300
24	Testosterone	—	299
25	Ciclopirox	—	88
26	Clenbuterol	—	300
27	Corticosterone	—	300
28	Daunorubicin	—	298
29	Dinoprostone	—	296
30	Epinephrine	—	299
31	Ethinyl Estradiol	—	300
32	Imatinib Mesylate	—	300
33	Isoproterenol Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on	—	299
34	Nisoldipine	—	297
35	Masoprocol	—	300
36	Norepinephrine Precursor of epinephrine that is secreted by	—	298
37	o-Phthalaldehyde	—	300
38	Oxyphenbutazone	—	300
39	pivampicillin	—	275
40	Potassium Dichromate Chromic acid (H2Cr2O7), dipotassium salt.	—	300
41	Salmeterol Xinafoate	—	227
42	Tilorone	—	300
43	Urea	—	297
44	Cholesterol	—	300
45	Progesterone	—	299
46	Gemfibrozil	—	297
47	Podophyllotoxin	—	14
48	Triiodothyronine	—	300
49	vinblastine sulfate	—	81
50	s adenosylhomocysteine	—	300

About the Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes Pathway

The Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes pathway is catalogued in Reactome (ID: R-HSA-9931510) and involves 6 genes. In the BiohacksAI corpus, 60 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CREB1, CREBBP, KMT2A, NR1D1, RORA.