Phosphorylation and nuclear translocation of the CRY:PER:kinase complex

Q: What compounds affect the Phosphorylation and nuclear translocation of the CRY:PER:kinase complex pathway?

38 compounds in the BiohacksAI corpus have documented interactions with genes in the Phosphorylation and nuclear translocation of the CRY:PER:kinase complex pathway (Reactome ID: R-HSA-9931530). These compounds target 8 genes within this pathway.

REACTOME PATHWAY

Reactome: R-HSA-99315308 genes38 compounds

The Phosphorylation and nuclear translocation of the CRY:PER:kinase complex pathway (Reactome ID: R-HSA-9931530) involves 8 genes and is affected by 38 compounds in the BiohacksAI evidence corpus. Compound-pathway associations are derived from target overlap: a compound is linked to this pathway if it targets ≥2 genes within the pathway.

Genes in this Pathway

CDK5 CSNK1D CSNK1E CSNK2A1 CSNK2A2 CSNK2B PPP1CA PPP1CC

Compounds Affecting Phosphorylation and nuclear translocation of the CRY:PER:kinase complex

#	Compound	Targets Hit	Studies
1	Apigenin 5,7,4'-trihydroxy-flavone,	—	300
2	fisetin	—	78
3	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	—	150
4	chrysin	—	300
5	sp600125	—	117
6	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	—	300
7	Quercetin	—	300
8	Kaempferols	—	300
9	myricetin-3-O-galactopyranoside [Supplementary Concept]	—	300
10	Vanillic Acid	—	300
11	ly294002	—	11
12	alsterpaullone	—	12
13	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	—	300
14	pictilisib	—	25
15	kenpaullone	—	8
16	egcg	—	300
17	Dichlororibofuranosylbenzimidazole	—	26
18	Adenylyl Imidodiphosphate 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid.	—	300
19	Anthralin	—	299
20	Hexachlorophene	—	300
21	Mometasone Furoate	—	292
22	Oxytetracycline	—	300
23	Thyroxine	—	994
24	Tannins Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS).	—	300
25	Aurintricarboxylic Acid	—	184
26	Calcimycin	—	216
27	Chlorhexidine	—	299
28	Clotrimazole	—	296
29	Fluspirilene	—	74
30	Tetracycline	—	300
31	Thyroxine	—	300
32	indirubin	—	300
33	hydroxyfasudil [Supplementary Concept]	—	11
34	Sorafenib	—	300
35	Axitinib	—	298
36	Afatinib	—	297
37	Dasatinib	—	299
38	Okadaic Acid	—	300

About the Phosphorylation and nuclear translocation of the CRY:PER:kinase complex Pathway

The Phosphorylation and nuclear translocation of the CRY:PER:kinase complex pathway is catalogued in Reactome (ID: R-HSA-9931530) and involves 8 genes. In the BiohacksAI corpus, 38 compounds have documented interactions with at least 2 genes in this pathway, establishing mechanistic relevance. Key pathway genes include CDK5, CSNK1D, CSNK1E, CSNK2A1, CSNK2A2.