A mitochondrial cytochrome P450 enzyme that catalyzes the 1-alpha-hydroxylation of 25-hydroxyvitamin D3 (also known as 25-hydroxycholecalciferol) in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP27B1 gene, converts 25-hydroxyvitamin D3 to 1-alpha,25-dihydroxyvitamin D3 which is the active form of VITAMIN D in regulating bone growth and calcium metabolism. This enzyme is also active on plant 25-hydroxyvitamin D2 (ergocalciferol).
25 Hydroxyvitamin D3 1 Alpha Hydroxylase has been studied across 18 research domains including 🦴 Bone & Joint, 🫘 Kidney, 🧬 Hormones, ⚡ Energy & Fatigue, 🫁 Liver & Detox. The primary research focus is 🦴 Bone & Joint with 97% of studies addressing this area.
This evidence profile for 25 Hydroxyvitamin D3 1 Alpha Hydroxylase is generated deterministically from 93 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.