A secreted protein of approximately 131 amino acids (depending on species) that regulates the synthesis of eumelanin (brown/black) pigments in MELANOCYTES. Agouti protein antagonizes the signaling of MELANOCORTIN RECEPTORS and has wide distribution including ADIPOSE TISSUE; GONADS; and HEART. Its overexpression in agouti mice results in uniform yellow coat color, OBESITY, and metabolic defects similar to type II diabetes in humans.
Agouti Signaling Protein has been studied across 13 research domains including ✨ Skin & Hair, 🔥 Metabolic, 🔬 Oncology, 🧬 Hormones, 🧘 Stress & Anxiety. The primary research focus is ✨ Skin & Hair with 46% of studies addressing this area.
This evidence profile for Agouti Signaling Protein is generated deterministically from 179 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.