A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.
Alpha Ketoglutarate Dependent Dioxygenase Fto has been studied across 15 research domains including 🔬 Oncology, 🔥 Metabolic, ⏳ Longevity & Aging, 🦴 Bone & Joint, 🫁 Respiratory. The primary research focus is 🔬 Oncology with 30% of studies addressing this area.
This evidence profile for Alpha Ketoglutarate Dependent Dioxygenase Fto is generated deterministically from 33 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.