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Apelin

A 77 amino acid secreted endogenous ligand for the angiotensin II receptor-like 1 protein (APELIN RECEPTOR) that is proteolytically cleaved into four smaller peptides: Apelin-36, Apelin-31, Apelin-28, and Apelin-13. It inhibits entry of HIV into cells that express both APJ and CD4 ANTIGEN and is highly expressed in breast milk, where it may modulate the neonatal immune response.

300+ PubMed studies analyzed · Evidence Score: 46.6

Research Domains

Apelin has been studied across 28 research domains including ❤️ Cardiovascular, 🔬 Oncology, 🔥 Metabolic, 🧘 Stress & Anxiety, 🫘 Kidney. The primary research focus is ❤️ Cardiovascular with 21% of studies addressing this area.

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This evidence profile for Apelin is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.