One of three major isoforms of apolipoprotein E. In humans, Apo E2 differs from APOLIPOPROTEIN E3 at one residue 158 where arginine is replaced by cysteine (R158--C). In contrast to Apo E3, Apo E2 displays extremely low binding affinity for LDL receptors (RECEPTORS, LDL) which mediate the internalization and catabolism of lipoprotein particles in liver cells. ApoE2 allelic homozygosity is associated with HYPERLIPOPROTEINEMIA TYPE III.
Apolipoprotein E2 has been studied across 17 research domains including 🔥 Metabolic, ❤️ Cardiovascular, 🧠 Neuroprotection, 🧬 Hormones, 🧠 Focus & Attention. The primary research focus is 🔥 Metabolic with 38% of studies addressing this area.
This evidence profile for Apolipoprotein E2 is generated deterministically from 208 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.