A family of actin binding proteins mostly in smooth muscle. Calponins include most abundant alpha-calponin (h1 or basic); beta-calponin; neutral calponin (h2 calponin); acidic calponin, SM22, and transgelin. Calponin family members have N-terminal single Calponin Homology (CH) domain and multiple C-terminus 23-amino acids long calponin-like repeats called CLICK-23. Calponins participate in modulation of smooth muscle contraction by binding to ACTINS (F- and G-Actins), CALMODULIN and TROPOMYSIN.
Calponins has been studied across 8 research domains including 🦴 Bone & Joint, 🏋️ Muscle & Hypertrophy, 💪 Strength & Power, 🧠 Focus & Attention, ❤️ Cardiovascular. The primary research focus is 🦴 Bone & Joint with 87% of studies addressing this area.
This evidence profile for Calponins is generated deterministically from 30 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.