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Cholesterol Side Chain Cleavage Enzyme

A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.

299+ PubMed studies analyzed · Evidence Score: 41.7

Research Domains

Cholesterol Side Chain Cleavage Enzyme has been studied across 18 research domains including ❤️ Cardiovascular, 🧬 Hormones, 🫘 Kidney, 💪 Strength & Power, ♀♂ Sexual Health. The primary research focus is ❤️ Cardiovascular with 80% of studies addressing this area.

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This evidence profile for Cholesterol Side Chain Cleavage Enzyme is generated deterministically from 299 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.