A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.
Cop9 Signalosome Complex has been studied across 20 research domains including 🔬 Oncology, 🔬 Inflammation, ⏳ Longevity & Aging, 🛡️ Immunity, 🧘 Stress & Anxiety. The primary research focus is 🔬 Oncology with 27% of studies addressing this area.
This evidence profile for Cop9 Signalosome Complex is generated deterministically from 100 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.