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Corticotropin Releasing Hormone

A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.

300+ PubMed studies analyzed · 4 RCTs · Evidence Score: 47

Research Domains

Corticotropin Releasing Hormone has been studied across 22 research domains including 🧘 Stress & Anxiety, 🫘 Kidney, 🌤️ Mood & Depression, 😴 Sleep, 🧬 Hormones. The primary research focus is 🧘 Stress & Anxiety with 24% of studies addressing this area.

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This evidence profile for Corticotropin Releasing Hormone is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.