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Deubiquitinating Enzyme Cyld

A deubiquitinase and tumor-suppressor protein that specifically cleaves LYSINE-63-linked polyubiquitin chains and also has endodeubiquitinase activity. It functions to regulate NF-KAPPA B and WNT SIGNALING PATHWAY activity, contributing to cell survival, proliferation, and differentiation. Mutations in the CYLD gene are associated with cases of FAMILIAL CYLINDROMATOSIS.

33+ PubMed studies analyzed · Evidence Score: 39.6

Research Domains

Deubiquitinating Enzyme Cyld has been studied across 11 research domains including 🔬 Oncology, 🛡️ Immunity, 🔬 Inflammation, ❤️ Cardiovascular, 🦴 Bone & Joint. The primary research focus is 🔬 Oncology with 46% of studies addressing this area.

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This evidence profile for Deubiquitinating Enzyme Cyld is generated deterministically from 33 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.