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Gtp Cyclohydrolase

An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).

299+ PubMed studies analyzed · 1 RCTs · Evidence Score: 44.9

Research Domains

Gtp Cyclohydrolase has been studied across 18 research domains including 🧠 Focus & Attention, 🌤️ Mood & Depression, 🧠 Neuroprotection, 🔬 Oncology, 🔬 Inflammation. The primary research focus is 🧠 Focus & Attention with 12% of studies addressing this area.

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This evidence profile for Gtp Cyclohydrolase is generated deterministically from 299 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.