An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell growth and proliferation. It consists of TOR SERINE-THREONINE KINASES; REGULATORY-ASSOCIATED PROTEIN OF MTOR (RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by SIROLIMUS; INSULIN; GROWTH FACTORS; PHOSPHATIDIC ACIDS; some amino acids or amino acid derivatives, and OXIDATIVE STRESS.
Mechanistic Target Of Rapamycin Complex 1 has been studied across 23 research domains including 🏋️ Muscle & Hypertrophy, 🔬 Oncology, ⏳ Longevity & Aging, 🔥 Metabolic, ⚡ Energy & Fatigue. The primary research focus is 🏋️ Muscle & Hypertrophy with 59% of studies addressing this area.
This evidence profile for Mechanistic Target Of Rapamycin Complex 1 is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.