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Methenyltetrahydrofolate Cyclohydrolase

An aminohydrolase that catalyzes the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate. In most higher eucaryotic organisms this enzyme also includes METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP) and FORMATE-TETRAHYDROFOLATE LIGASE activities.

111+ PubMed studies analyzed · 1 RCTs · Evidence Score: 45.5

Research Domains

Methenyltetrahydrofolate Cyclohydrolase has been studied across 8 research domains including ⚡ Energy & Fatigue, 🫁 Liver & Detox, 🔬 Oncology, 🧠 Focus & Attention, 🔥 Metabolic. The primary research focus is ⚡ Energy & Fatigue with 15% of studies addressing this area.

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This evidence profile for Methenyltetrahydrofolate Cyclohydrolase is generated deterministically from 111 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.