A 36-amino acid pancreatic hormone that is secreted mainly by endocrine cells found at the periphery of the ISLETS OF LANGERHANS and adjacent to cells containing SOMATOSTATIN and GLUCAGON. Pancreatic polypeptide (PP), when administered peripherally, can suppress gastric secretion, gastric emptying, pancreatic enzyme secretion, and appetite. A lack of pancreatic polypeptide (PP) has been associated with OBESITY in rats and mice.
Pancreatic Polypeptide has been studied across 12 research domains including 🔥 Metabolic, 🧬 Hormones, 🦠 Gut & Microbiome, 🔬 Oncology, 🫁 Liver & Detox. The primary research focus is 🔥 Metabolic with 22% of studies addressing this area.
The following compounds share molecular targets with Pancreatic Polypeptide, based on binding affinity data from BindingDB and ChEMBL. Sorted by shared target overlap.
This evidence profile for Pancreatic Polypeptide is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.