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Phosphofructokinase 2

An allosteric enzyme that regulates glycolysis and gluconeogenesis by catalyzing the transfer of a phosphate group from ATP to fructose-6-phosphate to yield fructose-2,6-bisphosphate, an allosteric effector for the other 6-phosphofructokinase, PHOSPHOFRUCTOKINASE-1. Phosphofructokinase-2 is bifunctional: the dephosphorylated form is a kinase and the phosphorylated form is a phosphatase that breaks down fructose-2,6-bisphosphate to yield fructose-6-phosphate.

168+ PubMed studies analyzed · Evidence Score: 44

Research Domains

Phosphofructokinase 2 has been studied across 18 research domains including 🔥 Metabolic, 🫁 Liver & Detox, 🔬 Oncology, ⚡ Energy & Fatigue, 🧬 Hormones. The primary research focus is 🔥 Metabolic with 30% of studies addressing this area.

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This evidence profile for Phosphofructokinase 2 is generated deterministically from 168 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.