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Sirtuin 1

A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in gene regulation.

300+ PubMed studies analyzed · 4 RCTs · Evidence Score: 45

Research Domains

Sirtuin 1 has been studied across 26 research domains including ⏳ Longevity & Aging, 🔬 Oncology, 🔬 Inflammation, 🔥 Metabolic, 🧘 Stress & Anxiety. The primary research focus is ⏳ Longevity & Aging with 97% of studies addressing this area.

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This evidence profile for Sirtuin 1 is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.