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Steroid 21 Hydroxylase

An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP21 gene, converts progesterones to precursors of adrenal steroid hormones (CORTICOSTERONE; HYDROCORTISONE). Defects in CYP21 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).

300+ PubMed studies analyzed · Evidence Score: 52.7

Research Domains

Steroid 21 Hydroxylase has been studied across 12 research domains including 🫘 Kidney, 🧬 Hormones, 🛡️ Immunity, 🔬 Oncology, 🫁 Liver & Detox. The primary research focus is 🫘 Kidney with 79% of studies addressing this area.

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This evidence profile for Steroid 21 Hydroxylase is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.