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Valosin Containing Protein

A highly-conserved AAA ATPase that functions in the biogenesis of the transitional ENDOPLASMIC RETICULUM and fragmentation and reassembly of the GOLGI APPARATUS during MITOSIS. It also functions in a complex with UFD1L and NPLOC4 proteins to export misfolded ubiquitinated proteins from the endoplasmic reticulum and outer mitochondrial membrane to the cytoplasm for degradation by the PROTEASOME and also plays a role in AUTOPHAGY of ubiquitinated proteins. It occurs in neuronal INCLUSION BODIES from patients with AMYOTROPHIC LATERAL SCLEROSIS and LEWY BODIES from PARKINSON DISEASE patients.

300+ PubMed studies analyzed · 1 RCTs · Evidence Score: 46.5

Research Domains

Valosin Containing Protein has been studied across 19 research domains including 🔬 Oncology, 🧠 Neuroprotection, ⚡ Energy & Fatigue, ⏳ Longevity & Aging, 🧘 Stress & Anxiety. The primary research focus is 🔬 Oncology with 21% of studies addressing this area.

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This evidence profile for Valosin Containing Protein is generated deterministically from 300 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.