A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.
Werner Syndrome Helicase has been studied across 10 research domains including 🔬 Oncology, ⏳ Longevity & Aging, 🧘 Stress & Anxiety, ⚡ Energy & Fatigue, 🔬 Inflammation. The primary research focus is 🔬 Oncology with 34% of studies addressing this area.
This evidence profile for Werner Syndrome Helicase is generated deterministically from 73 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.
Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.