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Werner Syndrome Helicase

A DNA-dependent helicase and 3'-5' exonuclease. It has 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang and binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and HOLLIDAY JUNCTIONS. Mutations in the WRN gene are associated with WERNER SYNDROME.

73+ PubMed studies analyzed · Evidence Score: 41.9

Research Domains

Werner Syndrome Helicase has been studied across 10 research domains including 🔬 Oncology, ⏳ Longevity & Aging, 🧘 Stress & Anxiety, ⚡ Energy & Fatigue, 🔬 Inflammation. The primary research focus is 🔬 Oncology with 34% of studies addressing this area.

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This evidence profile for Werner Syndrome Helicase is generated deterministically from 73 PubMed-indexed studies. All data is corpus-verified with Merkle proofs. BiohacksAI does not provide medical advice. Always consult a healthcare professional before starting any supplement regimen.

Data source: PubMed/MEDLINE (NLM). Corpus version: current. Patent pending (EVE-PAT-2026-001). © 2026 Organiq Sweden AB.