What compounds target CYP1A2?

BiohacksAI has identified 230 compounds that interact with CYP1A2 (cytochrome P450 family 1 subfamily A member 2). Top compounds include: Phenacetin, Apigenin 5,7,4'-trihydroxy-flavone,, Quercetin, Melatonin, Disulfiram. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is CYP1A2 (cytochrome P450 family)?

CYP1A2 is cytochrome P450 family 1 subfamily A member 2. It is a molecular target for 230 compounds documented in PubMed bioassay data. UniProt ID: P05177. NCBI Gene ID: 1544.

CYP1A2

MOLECULAR TARGET

cytochrome P450 family 1 subfamily A member 2

UniProt: P05177 NCBI Gene: 1544230 compounds

CYP1A2 (cytochrome P450 family 1 subfamily A member 2) is targeted by 230 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting CYP1A2

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Phenacetin	2.64	13
2	Apigenin 5,7,4'-trihydroxy-flavone,	2.56	12
3	Quercetin	2.48	11
4	Melatonin	2.40	10
5	Disulfiram	2.40	10
6	chrysin	2.30	9
7	Flutamide	2.30	9
8	Genistein	2.20	8
9	Kaempferols	2.20	8
10	Clotrimazole	2.20	8
11	Methoxsalen	2.20	8
12	Piribedil	2.20	8
13	Riluzole	2.20	8
14	Sulindac	2.20	8
15	Thiabendazole 2-Substituted benzimidazole first introduced in 1962. It is active against	2.20	8
16	Pueraria	2.08	7
17	Isoniazid Antibacterial agent used primarily as	2.08	7
18	Leflunomide	2.08	7
19	Nocodazole Nocodazole is	2.08	7
20	Luteolin 5,7,3',4'-tetrahydroxy-flavone,	1.95	6
21	Clofibrate	1.95	6
22	Diuron	1.95	6
23	Emodin Purgative anthraquinone found in several plants, especially RHAMNUS PURSHIANA. It was formerly used as	1.95	6
24	Ethoxyquin Antioxidant; also	1.95	6
25	Secologanin Tryptamine Alkaloids Compounds formed by condensation of secologanin with tryptamine resulting in	1.95	6
26	Vitamin K 3	1.95	6
27	Miconazole	1.95	6
28	Niclosamide	1.95	6
29	Perphenazine	1.95	6
30	Quipazine	1.95	6
31	Tolazamide	1.95	6
32	myricetin-3-O-galactopyranoside [Supplementary Concept]	1.79	5
33	Fenofibrate	1.79	5
34	tyrphostin ag 1478	1.79	5
35	Methylene Blue	1.61	4
36	propyl gallate	1.61	4
37	Anastrozole	1.61	4
38	Bufexamac	1.61	4
39	Camptothecin	1.61	4
40	Carbaryl	1.61	4
41	Carboxin	1.61	4
42	Dinitrochlorobenzene	1.61	4
43	Etazolate	1.61	4
44	Ethidium	1.61	4
45	fluoranthene	1.61	4
46	Linuron	1.61	4
47	ly294002	1.61	4
48	Melphalan	1.61	4
49	Mestranol	1.61	4
50	Nisoldipine	1.61	4

Showing top 50 of 230 compounds. Use the BiohacksAI search to explore all CYP1A2 modulators.

About CYP1A2 as a Drug Target

CYP1A2 (cytochrome P450 family 1 subfamily A member 2) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 230 compounds with documented CYP1A2 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

CYP1A2 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.