What compounds target HIF1A?

BiohacksAI has identified 45 compounds that interact with HIF1A (hypoxia inducible factor 1 subunit alpha). Top compounds include: Emetine, cycloheximide, Topotecan, Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone, Gliotoxin. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HIF1A (hypoxia inducible factor)?

HIF1A is hypoxia inducible factor 1 subunit alpha. It is a molecular target for 45 compounds documented in PubMed bioassay data. UniProt ID: Q16665. NCBI Gene ID: 3091.

HIF1A

MOLECULAR TARGET

hypoxia inducible factor 1 subunit alpha

UniProt: Q16665 NCBI Gene: 309145 compounds

HIF1A (hypoxia inducible factor 1 subunit alpha) is targeted by 45 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HIF1A

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Emetine	2.20	8
2	cycloheximide	2.08	7
3	Topotecan	1.79	5
4	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	1.39	3
5	Gliotoxin	1.39	3
6	Strophanthidin 3 beta,5,14-Trihydroxy-19-oxo-5 beta-card-20(22)-enolide.	1.39	3
7	Bortezomib	1.10	2
8	Harmaline	1.10	2
9	Harmine Alkaloid isolated from seeds of PEGANUM HARMALA; ZYGOPHYLLACEAE. It is identical to banisterine, or telepathine, from Banisteria caapi and is	1.10	2
10	Loratadine	1.10	2
11	oxatomide [Supplementary Concept] structure;	1.10	2
12	triolimus [Supplementary Concept]	1.10	2
13	Apigenin 5,7,4'-trihydroxy-flavone,	0.69	1
14	chrysin	0.69	1
15	Hydrocortisone	0.69	1
16	egcg	0.69	1
17	Kaempferols	0.69	1
18	Quercetin	0.69	1
19	Resveratrol	0.69	1
20	2-Chloroadenosine 2-Chloroadenosine.	0.69	1
21	ag490	0.69	1
22	Beclomethasone	0.69	1
23	Camptothecin	0.69	1
24	celastrol	0.69	1
25	Clotrimazole	0.69	1
26	cycloserine	0.69	1
27	Dequalinium	0.69	1
28	Desoximetasone	0.69	1
29	Digitoxigenin 3 beta,14-Dihydroxy-5 beta-card-20(22)enolide.	0.69	1
30	Digoxigenin 3 beta,12 beta,14-Trihydroxy-5 beta-card-20(22)-enolide.	0.69	1
31	Digoxin	0.69	1
32	Epinephrine	0.69	1
33	Ethoxyquin Antioxidant; also	0.69	1
34	Fusaric Acid	0.69	1
35	gedunin	0.69	1
36	Hesperidin	0.69	1
37	Hydrocortisone	0.69	1
38	Mometasone Furoate	0.69	1
39	Niclosamide	0.69	1
40	Nisoldipine	0.69	1
41	Oxytetracycline	0.69	1
42	Phenoxybenzamine	0.69	1
43	sp600125	0.69	1
44	Tubercidin	0.69	1
45	tyrphostin 9	0.69	1

About HIF1A as a Drug Target

HIF1A (hypoxia inducible factor 1 subunit alpha) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 45 compounds with documented HIF1A interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HIF1A inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.