What compounds target HTR1E?

BiohacksAI has identified 20 compounds that interact with HTR1E (5-hydroxytryptamine receptor 1E). Top compounds include: Sumatriptan, Methysergide, Metergoline, Ergotamine, Methylergonovine. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is HTR1E (5-hydroxytryptamine receptor 1E)?

HTR1E is 5-hydroxytryptamine receptor 1E. It is a molecular target for 20 compounds documented in PubMed bioassay data. UniProt ID: P28566. NCBI Gene ID: 3354.

HTR1E

MOLECULAR TARGET

5-hydroxytryptamine receptor 1E

UniProt: P28566 NCBI Gene: 335420 compounds

HTR1E (5-hydroxytryptamine receptor 1E) is targeted by 20 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting HTR1E

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	Sumatriptan	2.48	11
2	Methysergide	2.40	10
3	Metergoline	2.20	8
4	Ergotamine	1.61	4
5	Methylergonovine	1.61	4
6	Quetiapine Fumarate	1.10	2
7	brl 15572	1.10	2
8	Dihydroergotamine	1.10	2
9	Dihydroergotamine	1.10	2
10	Ergonovine	1.10	2
11	Fluspirilene	1.10	2
12	Lysergic Acid Diethylamide Semisynthetic derivative of ergot (Claviceps purpurea). It has complex effects on serotonergic systems including antagonism at some peripheral serotonin receptors, both agonist and antagonist actions at central nervous system serotonin receptors, and possibly effects on serotonin turnover. It is	1.10	2
13	Yohimbine	1.10	2
14	Lisuride	0.69	1
15	Mescaline Hallucinogenic alkaloid isolated from	0.69	1
16	Phentolamine	0.69	1
17	Pindolol	0.69	1
18	Podophyllotoxin	0.69	1
19	triflupromazine hydrochloride	0.69	1
20	vinblastine sulfate	0.69	1

About HTR1E as a Drug Target

HTR1E (5-hydroxytryptamine receptor 1E) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 20 compounds with documented HTR1E interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

HTR1E inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.