What compounds target RPS6KA1?

BiohacksAI has identified 48 compounds that interact with RPS6KA1 (ribosomal protein S6 kinase A1). Top compounds include: sb 203580, tofacitinib, alvocidib, tozasertib, vandetanib. Each compound is ranked by evidence score derived from PubMed bioassay confidence and assay count.

What is RPS6KA1 (ribosomal protein S6)?

RPS6KA1 is ribosomal protein S6 kinase A1. It is a molecular target for 48 compounds documented in PubMed bioassay data. UniProt ID: Q15418. NCBI Gene ID: 6195.

RPS6KA1

MOLECULAR TARGET

ribosomal protein S6 kinase A1

UniProt: Q15418 NCBI Gene: 619548 compounds

RPS6KA1 (ribosomal protein S6 kinase A1) is targeted by 48 compounds in the BiohacksAI evidence corpus, derived from PubMed bioassay data. Each compound is ranked by confidence score (log-normalized assay count × evidence quality).

Compounds Targeting RPS6KA1

Ranked by bioassay confidence score (PubChem active assay count × evidence quality).

#	Compound	Confidence	Active Assays
1	sb 203580	4.92	136
2	tofacitinib	4.65	104
3	alvocidib	4.52	91
4	tozasertib	4.33	75
5	vandetanib	4.30	73
6	ruxolitinib	4.23	68
7	ceritinib	4.19	65
8	bi 2536	4.01	54
9	midostaurin	3.85	46
10	brigatinib	3.81	44
11	silmitasertib	3.78	43
12	neratinib	3.66	38
13	sb 202190	3.64	37
14	nintedanib	3.61	36
15	canertinib	3.53	33
16	sb 216763	3.53	33
17	tae 684	3.43	30
18	fedratinib	3.40	29
19	gilteritinib	3.40	29
20	gf 109203	3.40	29
21	mln 8054	3.33	27
22	sb 431542	3.33	27
23	dorsomorphin	3.14	22
24	bisindolylmaleimide ix	3.14	22
25	dovitinib	3.09	21
26	jnj 7706621	3.09	21
27	at 9283	3.09	21
28	lestaurtinib	3.04	20
29	pf 03758309	3.00	19
30	ruboxistaurin	2.94	18
31	orantinib	2.89	17
32	r 406	2.83	16
33	k 252a	2.83	16
34	bms 345541	2.71	14
35	kw 2449	2.64	13
36	gsk 690693	2.64	13
37	su 014813	2.20	8
38	rebastinib	2.20	8
39	enzastaurin	2.08	7
40	tg100 115	2.08	7
41	gsk 269962a	2.08	7
42	gsk 180736a	2.08	7
43	uprosertib	1.95	6
44	sra 737	1.95	6
45	pf 03814735	1.79	5
46	fisetin	0.69	1
47	hydroxyfasudil [Supplementary Concept]	0.69	1
48	Sorafenib	0.69	1

About RPS6KA1 as a Drug Target

RPS6KA1 (ribosomal protein S6 kinase A1) is a well-characterized molecular target in biomedical research. BiohacksAI tracks 48 compounds with documented RPS6KA1 interaction from PubChem bioassay data, cross-referenced with PubMed clinical evidence. The confidence score reflects the log-normalized count of active PubChem assays, weighted by evidence quality from the BiohacksAI corpus.

RPS6KA1 inhibitors, activators, and modulators are of interest in research areas including longevity, metabolic health, and neurological function. Each compound profile includes evidence score, RCT count, human study ratio, research velocity, and domain relevance.