Compounds That Target AKT1

Akt serine/threonine kinase 1 · 60 compounds in BiohacksAI corpus

AKT1 (protein kinase B alpha) is a central node in the PI3K/AKT/mTOR signaling pathway governing cell survival, proliferation, and glucose metabolism. It is overactivated in numerous cancers and metabolic diseases. The 60 compounds targeting AKT1 span pharmaceutical kinase inhibitors and natural compounds including curcumin, quercetin, and resveratrol, which show evidence of AKT pathway modulation.

View AKT1 target page →UniProt: P31750 ↗

Most Studied Compounds for AKT1

Allium Sativum

500+

studies

Juglans Regia

500+

studies

Zingiber Officinale

498+

studies

Rapamycin

300+

studies

Quercetin

300+

studies

Panax Ginseng

300+

studies

Ginkgo Biloba

299+

studies

Luteolin

150+

studies

Ha1077

11+

studies

All 50 Compounds — Ranked by Evidence

Miltefosine

5.81

confidence

Midostaurin

3.85

confidence

Naphthoquinone

3.58

confidence

Linifanib

3.33

confidence

Lestaurtinib

3.04

confidence

Perifosine

2.89

confidence

Mk 2206

2.83

confidence

Capivasertib

2.77

confidence

Gsk 690693

2.64

confidence

Pf 04691502

2.64

confidence

Ipatasertib

2.20

confidence

A 443654

2.20

confidence

Gsk 269962a

2.08

confidence

Uprosertib

1.95

confidence

Borussertib

1.95

confidence

Afuresertib

1.79

confidence

Rapamycin

300+

studies

1.10

confidence

Ha1077

11+

studies

1.10

confidence

Glycyrrhiza Uralensis

1.00

confidence

Salvia Miltiorrhiza

1.00

confidence

Sanguisorba Officinalis

1.00

confidence

Zingiber Officinale

498+

studies

1.00

confidence

Luteolin

150+

studies

0.69

confidence

Quercetin

300+

studies

0.69

confidence

Achyranthes Bidentata

0.50

confidence

Allium Sativum

500+

studies

0.50

confidence

Aloe Vera

0.50

confidence

Apis Mellifera

0.50

confidence

Aquilaria Sinensis

0.50

confidence

Belamcanda Chinensis

0.50

confidence

Bupleurum Chinense

0.50

confidence

Carthamus Tinctorius

0.50

confidence

Coix Lacryma

0.50

confidence

Ephedra Sinica

0.50

confidence

Epimedium Brevicornum

0.50

confidence

Eucommia Ulmoides

0.50

confidence

Forsythia Suspensa

0.50

confidence

Fritillaria Cirrhosa

0.50

confidence

Gastrodia Elata

0.50

confidence

Ginkgo Biloba

299+

studies

0.50

confidence

Glycine Max

0.50

confidence

Juglans Regia

500+

studies

0.50

confidence

Ligusticum Chuanxiong

0.50

confidence

Lonicera Japonica

0.50

confidence

Morus Alba

0.50

confidence

Panax Ginseng

300+

studies

0.50

confidence

Panax Notoginseng

0.50

confidence

Peucedanum Praeruptorum

0.50

confidence

Polygonum Cuspidatum

0.50

confidence

Poria Cocos

0.50

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for AKT1 (Akt serine/threonine kinase 1). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: AKT1 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.