Compounds That Target CDK8

cyclin dependent kinase 8 · 134 compounds in BiohacksAI corpus

CDK8 (cyclin dependent kinase 8) is a protein kinase involved in intracellular signal transduction. Kinases phosphorylate downstream substrates to regulate cell growth, survival, and metabolism. The 134 compounds targeting CDK8 include both pharmaceutical inhibitors and natural compounds with evidence of kinase modulation, ranked by evidence strength from the BiohacksAI corpus.

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Most Studied Compounds for CDK8

Allium Sativum

500+

studies

Curcuma Longa

500+

studies

Centella Asiatica

499+

studies

Sorafenib

300+

studies

Ginkgo Biloba

299+

studies

Alsterpaullone

12+

studies

Ha1077

11+

studies

Ly294002

11+

studies

All 52 Compounds — Ranked by Evidence

Alvocidib

4.52

confidence

Foretinib

4.34

confidence

Ponatinib

4.26

confidence

Doramapimod

4.06

confidence

Quizartinib

3.99

confidence

Dinaciclib

3.87

confidence

Vatalanib

3.69

confidence

Tpck

3.47

confidence

Bms 387032

3.47

confidence

Linifanib

3.33

confidence

Lestaurtinib

3.04

confidence

Plx 4720

2.71

confidence

Cp 724714

2.56

confidence

Ast 487

2.56

confidence

Ct 7001

2.20

confidence

Sel 120 Free Base

1.95

confidence

Voruciclib

1.79

confidence

Sorafenib

300+

studies

1.39

confidence

Ha1077

11+

studies

1.10

confidence

Paeonia Lactiflora

1.00

confidence

Morus Alba

1.00

confidence

Nelumbo Nucifera

1.00

confidence

Agastache Rugosa

1.00

confidence

Allium Sativum

500+

studies

1.00

confidence

Allium Tuberosum

1.00

confidence

Aloe Vera

1.00

confidence

Arctium Lappa

1.00

confidence

Artemisia Capillaris

1.00

confidence

Aster Tataricus

1.00

confidence

Bupleurum Chinense

1.00

confidence

Carthamus Tinctorius

1.00

confidence

Centella Asiatica

499+

studies

1.00

confidence

Chaenomeles Speciosa

1.00

confidence

Citrus Reticulata

1.00

confidence

Crataegus Pinnatifida

1.00

confidence

Curcuma Longa

500+

studies

1.00

confidence

Cynomorium Songaricum

1.00

confidence

Ephedra Sinica

1.00

confidence

Eriobotrya Japonica

1.00

confidence

Eucommia Ulmoides

1.00

confidence

Forsythia Suspensa

1.00

confidence

Fritillaria Cirrhosa

1.00

confidence

Gastrodia Elata

1.00

confidence

Ginkgo Biloba

299+

studies

1.00

confidence

Glycyrrhiza Uralensis

1.00

confidence

Lilium Lancifolium

1.00

confidence

Litchi Chinensis

1.00

confidence

Lithospermum Erythrorhizon

1.00

confidence

Lobelia Chinensis

1.00

confidence

Lonicera Japonica

1.00

confidence

Ly294002

11+

studies

0.69

confidence

Alsterpaullone

12+

studies

0.69

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for CDK8 (cyclin dependent kinase 8). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: CDK8 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.