BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
BiohacksAI is an evolving scientific literature platform. New compounds and evidence are indexed continuously.
B
○
BiohacksAI/Targets/COMT/Compounds

Compounds That Target COMT

catechol-O-methyltransferase · 125 compounds in BiohacksAI corpus

COMT (catechol-O-methyltransferase) is a biological target with 125 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into COMT modulation for therapeutic and biohacking applications.

View COMT target page →UniProt: P22734 ↗
Most Studied Compounds for COMT
1
Allium Sativum
500+
studies
2
Curcuma Longa
500+
studies
3
Centella Asiatica
499+
studies
4
Foeniculum Vulgare
499+
studies
5
Caffeic Acid
300+
studies
6
Panax Ginseng
300+
studies
7
Ginkgo Biloba
299+
studies
8
Areca Catechu
199+
studies
All 50 Compounds — Ranked by Evidence
1
Oxyquinoline
3.85
confidence
2
Tolcapone
3.76
confidence
3
Entacapone
3.43
confidence
4
Caffeic Acid
300+
studies
1.10
confidence
5
Achyranthes Bidentata
1.00
confidence
6
Aconitum Carmichaelii
1.00
confidence
7
Agastache Rugosa
1.00
confidence
8
Allium Sativum
500+
studies
1.00
confidence
9
Aloe Vera
1.00
confidence
10
Arctium Lappa
1.00
confidence
11
Areca Catechu
199+
studies
1.00
confidence
12
Artemisia Annua
1.00
confidence
13
Artemisia Argyi
1.00
confidence
14
Artemisia Capillaris
1.00
confidence
15
Atractylodes Macrocephala
1.00
confidence
16
Bufo Bufo
1.00
confidence
17
Bupleurum Chinense
1.00
confidence
18
Carthamus Tinctorius
1.00
confidence
19
Centella Asiatica
499+
studies
1.00
confidence
20
Chaenomeles Speciosa
1.00
confidence
21
Cimicifuga Heracleifolia
1.00
confidence
22
Citrus Reticulata
1.00
confidence
23
Crataegus Pinnatifida
1.00
confidence
24
Curcuma Longa
500+
studies
1.00
confidence
25
Cuscuta Chinensis
1.00
confidence
26
Cynomorium Songaricum
1.00
confidence
27
Dimocarpus Longan
1.00
confidence
28
Ephedra Sinica
1.00
confidence
29
Eriobotrya Japonica
1.00
confidence
30
Eucommia Ulmoides
1.00
confidence
31
Foeniculum Vulgare
499+
studies
1.00
confidence
32
Forsythia Suspensa
1.00
confidence
33
Fritillaria Cirrhosa
1.00
confidence
34
Gastrodia Elata
1.00
confidence
35
Ginkgo Biloba
299+
studies
1.00
confidence
36
Glycine Max
1.00
confidence
37
Glycyrrhiza Uralensis
1.00
confidence
38
Inula Japonica
1.00
confidence
39
Ligusticum Chuanxiong
1.00
confidence
40
Lilium Lancifolium
1.00
confidence
41
Litchi Chinensis
1.00
confidence
42
Lithospermum Erythrorhizon
1.00
confidence
43
Lobelia Chinensis
1.00
confidence
44
Lonicera Japonica
1.00
confidence
45
Mentha Haplocalyx
1.00
confidence
46
Morus Alba
1.00
confidence
47
Nelumbo Nucifera
1.00
confidence
48
Paeonia Lactiflora
1.00
confidence
49
Panax Ginseng
300+
studies
1.00
confidence
50
Panax Notoginseng
1.00
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for COMT (catechol-O-methyltransferase). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: COMT target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.