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BiohacksAI/Targets/CYP3A4/Compounds

Compounds That Target CYP3A4

cytochrome P450 family 3 subfamily A member 4 · 368 compounds in BiohacksAI corpus

CYP3A4 (cytochrome P450 family 3 subfamily A member 4) is a cytochrome P450 enzyme involved in the metabolism of drugs, hormones, and dietary compounds. CYP enzymes are critical determinants of pharmacokinetics and drug-herb interactions. The 368 compounds listed here have documented interactions with CYP3A4 based on BindingDB inhibition and binding assay data, making this resource valuable for assessing compound safety and interaction profiles.

View CYP3A4 target page →UniProt: P08684 ↗
Most Studied Compounds for CYP3A4
1
Fluoxetine
1.0k+
studies
2
Methoxypsoralen
300+
studies
3
Apigenin
300+
studies
4
Lovastatin
300+
studies
5
Piribedil
300+
studies
6
Quercetin
300+
studies
7
Ethinyl Estradiol
300+
studies
8
Piperonyl Butoxide
300+
studies
9
Rotenone
300+
studies
10
Genistein
300+
studies
All 50 Compounds — Ranked by Evidence
1
Nifedipine
5.34
confidence
2
Indinavir
4.84
confidence
3
Sirolimus
4.82
confidence
4
Diltiazem
4.74
confidence
5
Amprenavir
4.64
confidence
6
Docetaxel
4.63
confidence
7
Nelfinavir
4.51
confidence
8
Tacrolimus Anhydrous
4.45
confidence
9
Paroxetine
4.39
confidence
10
Mibefradil
4.26
confidence
11
Gentian Violet
4.03
confidence
12
Bifonazole
3.71
confidence
13
Abiraterone
3.66
confidence
14
Ritonavir
298+
studies
3.47
confidence
15
Candesartan
3.47
confidence
16
Metyrapone
3.30
confidence
17
Idebenone
3.22
confidence
18
Benzylimidazole
2.89
confidence
19
Tamibarotene
2.89
confidence
20
Closantel
2.71
confidence
21
Liarozole
2.71
confidence
22
Clotrimazoleheterocyclic
2.64
confidence
23
Disulfiram
297+
studies
2.48
confidence
24
Methoxypsoralen
300+
studies
2.48
confidence
25
Miconazole
298+
studies
2.48
confidence
26
Sulconazole
2.48
confidence
27
Oxiconazole
2.48
confidence
28
Apigenin
300+
studies
2.40
confidence
29
Lacidipine
2.40
confidence
30
Glyburide
298+
studies
2.30
confidence
31
Amitifadine
2.30
confidence
32
Lovastatin
300+
studies
2.20
confidence
33
Maprotiline
299+
studies
2.20
confidence
34
Piribedil
300+
studies
2.20
confidence
35
Mosapride
2.20
confidence
36
Quercetin
300+
studies
2.08
confidence
37
Ethinyl Estradiol
300+
studies
2.08
confidence
38
Isoniazid
299+
studies
2.08
confidence
39
Leflunomide
297+
studies
2.08
confidence
40
Piperonyl Butoxide
300+
studies
2.08
confidence
41
Rotenone
300+
studies
2.08
confidence
42
Gsk778
2.08
confidence
43
Fluoxetine
1.0k+
studies
1.95
confidence
44
Genistein
300+
studies
1.95
confidence
45
Aprepitant
297+
studies
1.95
confidence
46
Celecoxib
295+
studies
1.95
confidence
47
Dequalinium
136+
studies
1.95
confidence
48
Dilazep
300+
studies
1.95
confidence
49
Emodin
300+
studies
1.95
confidence
50
Fulvestrant
295+
studies
1.95
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for CYP3A4 (cytochrome P450 family 3 subfamily A member 4). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: CYP3A4 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.