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BiohacksAI/Targets/DHFR/Compounds

Compounds That Target DHFR

dihydrofolate reductase · 138 compounds in BiohacksAI corpus

DHFR (dihydrofolate reductase) is a biological target with 138 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into DHFR modulation for therapeutic and biohacking applications.

View DHFR target page →UniProt: P00374 ↗
Most Studied Compounds for DHFR
1
Curcuma Longa
500+
studies
2
Foeniculum Vulgare
499+
studies
3
Panax Ginseng
300+
studies
4
Egcg
300+
studies
5
Pemetrexed
299+
studies
6
Ginkgo Biloba
299+
studies
7
Sulfadiazine
298+
studies
8
Leucovorin
297+
studies
9
Folic Acid
296+
studies
10
Amethopterin
289+
studies
All 54 Compounds — Ranked by Evidence
1
Gentamicin
6.30
confidence
2
Methotrexate
6.00
confidence
3
Trimethoprim
5.65
confidence
4
Pyrimethamine
5.36
confidence
5
Amethopterin
289+
studies
5.02
confidence
6
Diflunisal
4.17
confidence
7
Mefenamic Acid
3.93
confidence
8
Raltitrexed
3.58
confidence
9
Teriflunomide
3.56
confidence
10
Brequinar
3.37
confidence
11
Pemetrexed
299+
studies
3.14
confidence
12
Dideazafolate
2.40
confidence
13
Pralatrexate
2.08
confidence
14
Polygonum Cuspidatum
1.00
confidence
15
Panax Notoginseng
1.00
confidence
16
Perilla Frutescens
1.00
confidence
17
Pinellia Ternata
1.00
confidence
18
Piper Nigrum
1.00
confidence
19
Achyranthes Bidentata
1.00
confidence
20
Agastache Rugosa
1.00
confidence
21
Allium Tuberosum
1.00
confidence
22
Aloe Vera
1.00
confidence
23
Anemarrhena Asphodeloides
1.00
confidence
24
Artemisia Annua
1.00
confidence
25
Artemisia Argyi
1.00
confidence
26
Artemisia Capillaris
1.00
confidence
27
Atractylodes Macrocephala
1.00
confidence
28
Bombyx Mori
1.00
confidence
29
Bupleurum Chinense
1.00
confidence
30
Carthamus Tinctorius
1.00
confidence
31
Chaenomeles Speciosa
1.00
confidence
32
Citrus Reticulata
1.00
confidence
33
Commiphora Myrrha
1.00
confidence
34
Crataegus Pinnatifida
1.00
confidence
35
Curcuma Longa
500+
studies
1.00
confidence
36
Eriobotrya Japonica
1.00
confidence
37
Eucommia Ulmoides
1.00
confidence
38
Foeniculum Vulgare
499+
studies
1.00
confidence
39
Forsythia Suspensa
1.00
confidence
40
Fritillaria Cirrhosa
1.00
confidence
41
Gastrodia Elata
1.00
confidence
42
Gentiana Macrophylla
1.00
confidence
43
Ginkgo Biloba
299+
studies
1.00
confidence
44
Glycine Max
1.00
confidence
45
Glycyrrhiza Uralensis
1.00
confidence
46
Lonicera Japonica
1.00
confidence
47
Magnolia Biondii
1.00
confidence
48
Morus Alba
1.00
confidence
49
Nelumbo Nucifera
1.00
confidence
50
Panax Ginseng
300+
studies
1.00
confidence
51
Sulfadiazine
298+
studies
0.69
confidence
52
Leucovorin
297+
studies
0.69
confidence
53
Folic Acid
296+
studies
0.69
confidence
54
Egcg
300+
studies
0.69
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for DHFR (dihydrofolate reductase). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: DHFR target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.