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BiohacksAI/Targets/DHFR
MOLECULAR TARGETUniProt: P00374

DHFR

dihydrofolate reductase

138 compounds · BiohacksAI corpus v20260307-01

138
compounds
Compounds
138
Gene Symbol
DHFR
NCBI Gene
1719

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About DHFR

DHFR (dihydrofolate reductase) is a biological target studied in biomedical research. The BiohacksAI corpus identifies 138 compounds with documented interactions with this target, based on BindingDB assay data and PubMed literature.

View DHFR on UniProt →
Compounds Targeting DHFR (50)
1
Gentamicin
6.30
confidence
2
Methotrexate
6.00
confidence
3
Trimethoprim
5.65
confidence
4
Pyrimethamine
5.36
confidence
5
Amethopterin
289
studies
5.02
confidence
6
Diflunisal
4.17
confidence
7
Mefenamic Acid
3.93
confidence
8
Raltitrexed
3.58
confidence
9
Teriflunomide
3.56
confidence
10
Brequinar
3.37
confidence
11
Pemetrexed
299
studies
3.14
confidence
12
Dideazafolate
2.40
confidence
13
Pralatrexate
2.08
confidence
14
Polygonum Cuspidatum
1.00
confidence
15
Panax Notoginseng
1.00
confidence
16
Perilla Frutescens
1.00
confidence
17
Pinellia Ternata
1.00
confidence
18
Piper Nigrum
0
studies
1.00
confidence
19
Achyranthes Bidentata
1.00
confidence
20
Agastache Rugosa
1.00
confidence
21
Allium Tuberosum
1.00
confidence
22
Aloe Vera
1.00
confidence
23
Anemarrhena Asphodeloides
1.00
confidence
24
Artemisia Annua
1.00
confidence
25
Artemisia Argyi
1.00
confidence
26
Artemisia Capillaris
1.00
confidence
27
Atractylodes Macrocephala
1.00
confidence
28
Bombyx Mori
1.00
confidence
29
Bupleurum Chinense
1.00
confidence
30
Carthamus Tinctorius
1.00
confidence
31
Chaenomeles Speciosa
1.00
confidence
32
Citrus Reticulata
1.00
confidence
33
Commiphora Myrrha
1.00
confidence
34
Crataegus Pinnatifida
1.00
confidence
35
Curcuma Longa
500
studies
1.00
confidence
36
Eriobotrya Japonica
1.00
confidence
37
Eucommia Ulmoides
1.00
confidence
38
Foeniculum Vulgare
499
studies
1.00
confidence
39
Forsythia Suspensa
1.00
confidence
40
Fritillaria Cirrhosa
1.00
confidence
41
Gastrodia Elata
1.00
confidence
42
Gentiana Macrophylla
1.00
confidence
43
Ginkgo Biloba
299
studies
1.00
confidence
44
Glycine Max
1.00
confidence
45
Glycyrrhiza Uralensis
1.00
confidence
46
Lonicera Japonica
1.00
confidence
47
Magnolia Biondii
1.00
confidence
48
Morus Alba
1.00
confidence
49
Nelumbo Nucifera
0
studies
1.00
confidence
50
Panax Ginseng
300
studies
1.00
confidence
Top 50 compounds by confidence score. Derived from BindingDB assay data.
Data Source
Corpusv20260307-01
SourceBindingDB · ChEMBL · PubMed

All data is computationally derived from published research. Not medical advice. Independent validation required.