BETABiohacksAI is a research tool for informational purposes only. All outputs are computational hypothesis candidates — not confirmed mechanisms, not medical advice, and not a substitute for professional medical judgment. Independent experimental validation is always required.
BiohacksAI is an evolving scientific literature platform. New compounds and evidence are indexed continuously.
B
○
BiohacksAI/Targets/DOT1L/Compounds

Compounds That Target DOT1L

DOT1 like histone lysine methyltransferase · 88 compounds in BiohacksAI corpus

DOT1L (DOT1 like histone lysine methyltransferase) is a biological target with 88 documented compound interactions in the BiohacksAI corpus. The compounds listed below have been identified through computational analysis of BindingDB binding assay data and PubMed literature. Each interaction is ranked by confidence score reflecting the breadth and strength of experimental evidence. This resource supports research into DOT1L modulation for therapeutic and biohacking applications.

View DOT1L target page →UniProt: Q8TEK3 ↗
Most Studied Compounds for DOT1L
1
Allium Sativum
500+
studies
2
Curcuma Longa
500+
studies
3
Portulaca Oleracea
500+
studies
4
Centella Asiatica
499+
studies
5
Foeniculum Vulgare
499+
studies
6
Zingiber Officinale
498+
studies
7
S Adenosylhomocysteine
300+
studies
8
Panax Ginseng
300+
studies
9
Ginkgo Biloba
299+
studies
10
Cyproheptadine
299+
studies
All 50 Compounds — Ranked by Evidence
1
Sinefungin
3.74
confidence
2
Iodotubercidin
3.30
confidence
3
Sangivamycin
3.00
confidence
4
S Adenosylhomocysteine
300+
studies
2.40
confidence
5
Agastache Rugosa
1.00
confidence
6
Allium Sativum
500+
studies
1.00
confidence
7
Artemisia Annua
1.00
confidence
8
Artemisia Argyi
1.00
confidence
9
Artemisia Capillaris
1.00
confidence
10
Atractylodes Macrocephala
1.00
confidence
11
Bupleurum Chinense
1.00
confidence
12
Centella Asiatica
499+
studies
1.00
confidence
13
Citrus Reticulata
1.00
confidence
14
Cnidium Monnieri
1.00
confidence
15
Curcuma Longa
500+
studies
1.00
confidence
16
Eriobotrya Japonica
1.00
confidence
17
Eucommia Ulmoides
1.00
confidence
18
Foeniculum Vulgare
499+
studies
1.00
confidence
19
Ginkgo Biloba
299+
studies
1.00
confidence
20
Ligusticum Chuanxiong
1.00
confidence
21
Litchi Chinensis
1.00
confidence
22
Lonicera Japonica
1.00
confidence
23
Mosla Chinensis
1.00
confidence
24
Nelumbo Nucifera
1.00
confidence
25
Panax Ginseng
300+
studies
1.00
confidence
26
Panax Notoginseng
1.00
confidence
27
Perilla Frutescens
1.00
confidence
28
Pinellia Ternata
1.00
confidence
29
Piper Nigrum
1.00
confidence
30
Portulaca Oleracea
500+
studies
1.00
confidence
31
Prunus Mume
1.00
confidence
32
Schisandra Chinensis
1.00
confidence
33
Taxillus Chinensis
1.00
confidence
34
Zingiber Officinale
498+
studies
1.00
confidence
35
Ziziphus Jujuba
1.00
confidence
36
Cyproheptadine
299+
studies
0.69
confidence
37
Achyranthes Bidentata
0.50
confidence
38
Aconitum Carmichaelii
0.50
confidence
39
Allium Fistulosum
0.50
confidence
40
Allium Tuberosum
0.50
confidence
41
Aloe Vera
0.50
confidence
42
Anemarrhena Asphodeloides
0.50
confidence
43
Apis Mellifera
0.50
confidence
44
Aquilaria Sinensis
0.50
confidence
45
Arctium Lappa
0.50
confidence
46
Areca Catechu
199+
studies
0.50
confidence
47
Aucklandia Lappa
0.50
confidence
48
Carthamus Tinctorius
0.50
confidence
49
Chaenomeles Speciosa
0.50
confidence
50
Coix Lacryma
0.50
confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for DOT1L (DOT1 like histone lysine methyltransferase). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: DOT1L target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.