Compounds That Target ESR1

estrogen receptor 1 · 420 compounds in BiohacksAI corpus

ESR1 (estrogen receptor alpha) is a nuclear receptor that mediates estrogen signaling across reproductive, cardiovascular, and bone tissues. It is a major target for both therapeutic agents and dietary phytoestrogens such as genistein, daidzein, and lignans. The 420 compounds with documented ESR1 interactions span synthetic ligands, selective estrogen receptor modulators (SERMs), and naturally occurring plant compounds.

View ESR1 target page →UniProt: P03372 ↗

Most Studied Compounds for ESR1

Norgestrel

300+

studies

Ethinyl Estradiol

300+

studies

Genistein

300+

studies

Zearalenone

300+

studies

Methyltestosterone

300+

studies

Dhea

300+

studies

Dehydroepiandrosterone

300+

studies

Kaempferol

300+

studies

Estrone

300+

studies

Rotenone

300+

studies

All 50 Compounds — Ranked by Evidence

Tamoxifen

5.88

confidence

Raloxifene

4.77

confidence

Isoliquiritigenin

4.50

confidence

Coumaric Acid

4.42

confidence

Gossypol

4.42

confidence

Caffeic Acid Phenethyl Ester

4.25

confidence

Diethylstilbestrol

4.06

confidence

Emate

3.89

confidence

Phloretin

3.71

confidence

Afimoxifene

3.69

confidence

Trismethoxyresveratrol

3.56

confidence

Levonorgestrel

292+

studies

3.09

confidence

Norgestrel

300+

studies

3.09

confidence

Resveratrol

298+

studies

3.04

confidence

Ethinyl Estradiol

300+

studies

3.00

confidence

Genistein

300+

studies

2.94

confidence

Zearalenone

300+

studies

2.94

confidence

Bithionol

2.89

confidence

Bazedoxifene

2.89

confidence

Methyltestosterone

300+

studies

2.83

confidence

Coumestrol

2.83

confidence

Dhea

300+

studies

2.77

confidence

Dehydroepiandrosterone

300+

studies

2.77

confidence

Fulvestrant

295+

studies

2.77

confidence

Raloxifene Hydrochloride

2.77

confidence

Kaempferol

300+

studies

2.71

confidence

Dactinomycin

297+

studies

2.71

confidence

Danazol

298+

studies

2.71

confidence

Estrone

300+

studies

2.71

confidence

Bisphenol A

2.71

confidence

Endoxifen

2.71

confidence

Tamoxifen Citrate

2.71

confidence

Ethisterone

119+

studies

2.64

confidence

Nandrolonepolycyclic

2.64

confidence

Rotenone

300+

studies

2.64

confidence

8z 345 Trimethoxystilbene

2.64

confidence

Apigenin

300+

studies

2.56

confidence

Dihydrotestosterone

300+

studies

2.56

confidence

Ethidium Bromide

300+

studies

2.56

confidence

Ethynodiol Diacetate

300+

studies

2.56

confidence

Flutamide

298+

studies

2.56

confidence

Reserpine

297+

studies

2.56

confidence

Diarylpropionitrile

2.56

confidence

Colchicineheterocyclic

2.48

confidence

Estriol

300+

studies

2.48

confidence

Mestranol

300+

studies

2.48

confidence

Norethindrone

300+

studies

2.48

confidence

Oxymetholone

298+

studies

2.48

confidence

Testosterone Propionate

300+

studies

2.48

confidence

Kurarinone

2.48

confidence

The compounds above were identified through computational analysis of BindingDB binding assay data and PubMed literature for ESR1 (estrogen receptor 1). Confidence scores reflect the strength and breadth of experimental evidence.

Explore related resources: ESR1 target overview · All biological targets · Biological pathways

Data from BindingDB and PubMed. For research purposes only. Not medical advice.